| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720 |
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klq@cw-bio.com |
| Products Intro: |
Product Name:WAY-388264-A
CAS:393129-91-4
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 15221909166 |
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product02@bidepharm.com |
| Products Intro: |
Product Name:4-(4-((4-(tert-Butyl)phenyl)sulfonyl)piperazin-1-yl)-5,6-dimethylthieno[2,3-d]pyrimidine
CAS:393129-91-4
Purity:98% Package:25mg;50mg;100mg; Remarks:BD01167535
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
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marketing@tsbiochem.com |
| Products Intro: |
Product Name:WAY-388264-A;WAY388264A,WAY 388264 A
CAS:393129-91-4
Purity:98% Package:500 mg
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| Company Name: |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
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| Tel: |
021-59167510 18117107507 |
| Email: |
vip@med-life.cn |
| Products Intro: |
Product Name:5-HT2B antagonist-1
CAS:393129-91-4
Purity:>=99% Package:200mg;50mg;10mM*1mLinDMSO;100mg;5mg;10mg;500mg;25mg
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| | 1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- Basic information |
| Product Name: | 1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- | | Synonyms: | WAY-388264-A;1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl-;WAY388264A,WAY 388264 A;4-(4-((4-(tert-Butyl)phenyl)sulfonyl)piperazin-1-yl)-5,6-dimethylthieno[2,3-d]pyrimidine;5-HT2B antagonist-1 | | CAS: | 393129-91-4 | | MF: | C11H14BrN5 | | MW: | 296.17 | | EINECS: | | | Product Categories: | | | Mol File: | 393129-91-4.mol |  |
| | 1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- Chemical Properties |
| Melting point | 137 °C | | Boiling point | 382.0±44.0 °C(Predicted) | | density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 9.96±0.40(Predicted) |
| | 1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- Usage And Synthesis |
| Biological Activity | 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease[1][2].
5-HT2B antagonist-1 (compound 5g) has some sodium channel binding activity with IC50 values in the range of 12.6 to 57.5 μM[1].5-HT2B antagonist-1 (coumpound 1-e) inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines[3].
5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) can reduce visceral hypersensitivity significantly in irritable bowel syndrome (IBS) rats[2]. | | References | [1]. Xiang Ma, et al. Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5644[2]. Yu Zhou, et al. Structure-Based Discovery of Novel and Selective 5-Hydroxytryptamine 2B Receptor Antagonists for the Treatment of Irritable Bowel Syndrome. J Med Chem. 2016 Jan 28;59(2):707-20.[3]. Huang Niu, et al. 5-HT2B Antagonists. WO2015158214 |
| | 1,3,5-Triazine-2,4-diamine, N2-(4-bromophenyl)-3,6-dihydro-6,6-dimethyl- Preparation Products And Raw materials |
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