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| | (S)-(+)-2-Amino-1-butanol Basic information |
| | (S)-(+)-2-Amino-1-butanol Chemical Properties |
| Melting point | -2 °C(lit.) | | alpha | [α]D20 +9～+11° (neat) | | Boiling point | 179-183 °C(lit.) | | density | 0.944 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.4521(lit.) | | Fp | 184 °F | | storage temp. | 2-8°C(protect from light) | | solubility | Soluble in water | | form | clear liquid | | pka | pK1: 9.52(+1) (25°C) | | color | Clear colorless to slightly yellowish viscous liquid | | optical activity | [α]20/D +10°, neat | | Water Solubility | 1000g/L at 25℃ | | Sensitive | Air Sensitive & Hygroscopic | | BRN | 1718930 | | CAS DataBase Reference | 5856-62-2(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 34-37-22 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2735 8/PG 3 | | WGK Germany | 3 | | RTECS | EK9625000 | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29221990 |
| | (S)-(+)-2-Amino-1-butanol Usage And Synthesis |
| Chemical Properties | clear colorless to slightly yellowish viscous | | Uses | (S)-(+)-2-Amino-1-butanol is a chiral amino alcohol that may be used in the synthesis of (S)-2-(6-benzylamino-9-isopropyl-9H-purin-2-ylamino) butan-1-ol, an (S)-enantiomer of roscovitine. It can also be used to synthesize homochiral 2-methylpyrroles. (S)-(+)-2-Amino-1-butanol is an intermediate for the synthesis of (S,S)-ethambutol, an antibacterial agent for treating tuberculosis. | | Purification Methods | They are purified by shaking with solid NaOH, filtering and distilling through a short column. The oxalate of the racemate has m 176o. They are strong bases and should be stored under N2 in the absence of CO2. The enantiomers have [] 20 ±12.5o (c 2, EtOH). [Johnson & Degering J Org Chem 8 7 1943, Nagao et al. J Org Chem 51 2392 1986, Santaniello et al. J Chem Soc, Perkin Trans 1 919 1985, Beilstein 4 H 291, 4 IV 1705.] |
| | (S)-(+)-2-Amino-1-butanol Preparation Products And Raw materials |
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