Valspodar

Valspodar Suppliers list
Company Name: Alpha Biopharmaceuticals Co., Ltd
Tel: +86-411-39042497 +8613921981412
Email: sales@alphabiopharm.com
Products Intro: Product Name:Valspodar
CAS:121584-18-7
Purity:>98% HPLC Package:5mg; 25mg; 100mg; 1g; 5g; 25g;100g Remarks:B0084
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: 21-51619050
Email: ivan@atkchemical.com
Products Intro: Product Name:Valspodar
CAS:121584-18-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:Valspodar
CAS:121584-18-7
Purity:98% HPLC LCMS Package:10G;20G
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:valspodar
CAS:121584-18-7
Purity:0.99 Package:1kg
Company Name: Zhuozhou Wenxi import and Export Co., Ltd
Tel: +8613111626072
Email: zzwenxi@126.com
Products Intro: Product Name:Valspodar
CAS:121584-18-7
Purity:99%+ HPLC Package:1KG;15USD|100KG;12USD|1000KG;10USD

Valspodar manufacturers

  • Valspodar
  • $1.00 / 1g
  • 2022-03-24
  • CAS:121584-18-7
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 1ton
  • Valspodar
  • $15.00 / 1KG
  • 2021-07-13
  • CAS:121584-18-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Valspodar
  • $15.00 / 1KG
  • 2021-07-10
  • CAS:121584-18-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Valspodar Basic information
Product Name:Valspodar
Synonyms:Valspodar;3'-Keto-bmt(1)-Val(2)-cyclosporin a;Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-;Sdz psc 833;Sdz-psc-833;Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl];6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA;Valspodar(PSC-833,AMdray)
CAS:121584-18-7
MF:C63H111N11O12
MW:1214.62
EINECS:1312995-182-4
Product Categories:Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
Mol File:121584-18-7.mol
Valspodar Structure
Valspodar Chemical Properties
Melting point 143-145°C
alpha D20 -255.1° (c = 0.5 in CHCl3)
Boiling point 1290.1±65.0 °C(Predicted)
density 1.015±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka12.45±0.70(Predicted)
form powder
color white to beige
Safety Information
WGK Germany 3
MSDS Information
Valspodar Usage And Synthesis
DescriptionPSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.
Chemical PropertiesWhite Solid
UsesValspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.
UsesAntineoplastic adjunct (chemosensitizer).
Brand nameAmdray (Novartis).
Biochem/physiol ActionsValspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.
Valspodar Preparation Products And Raw materials
Tag:Valspodar(121584-18-7) Related Product Information
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