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Valspodar

Valspodar Suppliers list
Company Name: BOC Sciences
Tel: +16314854226
Email: inquiry@bocsci.com
Products Intro: Product Name:Valspodar
CAS:121584-18-7
Purity:>=95% Remarks:BOC Sciences also provides custom synthesis services for Valspodar.
Company Name: Alpha Biopharmaceuticals Co., Ltd
Tel: +86-411-39042497 +8613921981412
Email: sales@alphabiopharm.com
Products Intro: Product Name:Valspodar
CAS:121584-18-7
Purity:>98% HPLC Package:5mg; 25mg; 100mg; 1g; 5g; 25g;100g Remarks:B0084
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Valspodar
CAS:121584-18-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:Valspodar
CAS:121584-18-7
Purity:98% HPLC LCMS Package:10G;20G
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:valspodar
CAS:121584-18-7
Purity:0.99 Package:1kg

Valspodar manufacturers

  • Valspodar
  • Valspodar pictures
  • $15.00 / 1KG
  • 2021-07-13
  • CAS:121584-18-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Valspodar
  • Valspodar pictures
  • $15.00 / 1KG
  • 2021-07-10
  • CAS:121584-18-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Valspodar Basic information
Product Name:Valspodar
Synonyms:Valspodar;3'-Keto-bmt(1)-Val(2)-cyclosporin a;Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-;Sdz psc 833;Sdz-psc-833;Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl];6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA;Valspodar(PSC-833,AMdray)
CAS:121584-18-7
MF:C63H111N11O12
MW:1214.62
EINECS:1312995-182-4
Product Categories:Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
Mol File:121584-18-7.mol
Valspodar Structure
Valspodar Chemical Properties
Melting point 143-145°C
alpha D20 -255.1° (c = 0.5 in CHCl3)
Boiling point 1290.1±65.0 °C(Predicted)
density 1.015±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka12.45±0.70(Predicted)
form powder
color white to beige
InChIKeyYJDYDFNKCBANTM-QCWCSKBGSA-N
Safety Information
WGK Germany 3
MSDS Information
Valspodar Usage And Synthesis
DescriptionPSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.
Chemical PropertiesWhite Solid
UsesValspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.
UsesValspodar(PSC-833), a 2nd-generation ABC transporter inhibitor, limits HCMV infection as demonstrated by the decrease in IE2 expression of virus-infected cells. As a cyclosporin D analog, it has been shown to be a much more effective inhibitor of MDR than cyclosporin A and to be less toxic[1-2].
UsesAntineoplastic adjunct (chemosensitizer).
DefinitionChEBI: SDZ PSC 833 is a homodetic cyclic peptide.
Brand nameAmdray (Novartis).
Biochem/physiol ActionsValspodar is a nonimmunosuppressive cyclosporin analog and potent P-glycoprotein (MDR1) inhibitor. Valspodar reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein.
CytotoxicityCells treated with increasing concentrations of valspodar over a 9-day period show minimal cytotoxicity. It appears to be neither immunosuppressive nor nephrotoxic with the ability to achieve levels in the blood (1 μm) capable of reversing drug resistance without excessive toxicity[1].
storageStore at -20°C
References[1] Friedenberg W, et al. Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95). Cancer, 2006; 106: 830-838.
[2] Parsons J, et al. Valspodar limits human cytomegalovirus infection and dissemination. Antiviral Research, 2021; 193: 105124.
Valspodar Preparation Products And Raw materials
Tag:Valspodar(121584-18-7) Related Product Information
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