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Leancare Ltd.
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2A PharmaChem USA
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(630) 737-0988 |
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| | Pimefylline Basic information |
| Product Name: | Pimefylline | | Synonyms: | 1,3-Dimethyl-7-[2-[(pyridin-3-yl)methylamino]ethyl]-1H-purine-2,6(3H,7H)-dione;3,7-Dihydro-1,3-dimethyl-7-[2-[(3-pyridylmethyl)amino]ethyl]-1H-purine-2,6-dione;ES 771;ES-771;Pimephylline;Pimefylline;Pimefyllinum | | CAS: | 10001-43-1 | | MF: | C15H18N6O2 | | MW: | 314.347 | | EINECS: | | | Product Categories: | | | Mol File: | 10001-43-1.mol |  |
| | Pimefylline Chemical Properties |
| Toxicity | LD50 in mice (mg/kg): 1900 orally, 402 i.v. (Suter, Zutter, 1973) |
| | Pimefylline Usage And Synthesis |
| Originator | Teonicon, Bracco, Italy ,1975 | | Definition | ChEBI: Pimefylline is an oxopurine. | | Manufacturing Process | 77 g 7-(β-bromoethyl)-theophylline (C.A. 50, 12071f) and 57.8 g 3picolylamine in 750 ml toluene were refluxed 16 hours with vigorous agitation. The 3-picolylamine hydrobromide formed was filtered off, and the filtrate was evaporated in a vacuum to about one-third of its original volume. About 300 to 400 ml diisopropyl ether were added, and the solution was seeded with a few pure crystals of the desired product.
7-(β-3'-picolylaminoethyl)-theophylline crystallized over a period of a few hours. It was filtered off with suction, washed with a little diisopropyl ether, and dried. The yield of crude product was 69.3 g (82%), its MP 103° to 106°C. The MP was 111° to 112°C after recrystallization from isopropyl acetate. The compound was identified by microanalysis.
39.3 g 7-(β-3'-picolylaminoethyl)-theophylline were dissolved in 300 ml boiling isopropanol, and 15.4 g nicotinic acid were added to the solution in which the acid promptly dissolved. The nicotinate formed crystallized after a short time. It was filtered with suction and dried. The yield was 52.3 g (95.5%). The MP of 159° to 160°C was not significantly changed by recrystallization from ethanol. | | Therapeutic Function | Coronary vasodilator |
| | Pimefylline Preparation Products And Raw materials |
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