磷氟康唑

磷氟康唑 更多供应商
公司名称: 上海波以尔化工有限公司  
联系电话:
产品介绍: 中文名称:2-(2,4-二氟苯基)-1,3-二(1H-1,2,4-三氮唑-1-基)丙基二氢磷酸酯
英文名称:Fosfluconazole
CAS:194798-83-9
公司名称: 孝感深远化工有限公司  
联系电话: 15527768850 0712-2580635
产品介绍: 中文名称:磷康唑
CAS:194798-83-9
公司名称: Wuhan NCE Biomedical Co.,Ltd.  
联系电话: 4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988
产品介绍: 中文名称:磷康唑
英文名称:Fosfluconazole
CAS:194798-83-9
纯度:99% HPLC 包装信息:100Mg, 1g, 5g,10g 备注:试剂级
公司名称: 南京生利德生物科技有限公司  
联系电话: 025-57798810
产品介绍: 中文名称:福司氟康唑
英文名称:Fosfluconazole
CAS:194798-83-9
纯度:98%
公司名称: AdooQ BioScience, LLC   
联系电话: +1 (866) 930-6790
产品介绍: 英文名称:Fosfluconazole
CAS:194798-83-9
纯度:98% 包装信息:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
最新发布供应信息
福司氟康唑_健竹科技公司
2021/1/9 9:07:30
磷康唑_紫萌科技有限公司
2021/1/9 9:07:30
磷氟康唑
生物活性靶点体外研究体内研究 MSDS 用途与合成方法 磷氟康唑价格(试剂级) 上下游产品信息
中文名称:磷氟康唑
中文同义词:福斯氟康唑杂质;氟氟康唑;福司氟康唑;2-(2,4-二氟苯基)-1,3-二(1H-1,2,4-三氮唑-1-基)丙基二氢磷酸酯;磷康唑;磷氟康唑(福司氟康唑);磷氟康唑
英文名称:Fosfluconazole
英文同义词:2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propyl dihydrogen phosphate;Prodif;Fosfluconazole, >=98%;PHARMA PRODUCT FLUCONAZOLE USP 2-(2,4-DIFLUOROPHENYL)-1,3-BIS(1,2,4-TRIAZOL-1-YL) PROPAN-2-OL;Dihydrogen phosphate ester;CS-969;Fosfluconazole(INN);1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-, 1-(dihydrogen phosphate)
CAS号:194798-83-9
分子式:C13H13F2N6O4P
分子量:386.25
EINECS号:1312995-182-4
相关类别:化学原药;医药原料;医药原料药;Amines;API;Chiral Reagents;Heterocycles
Mol文件:194798-83-9.mol
磷氟康唑
磷氟康唑 性质
熔点 223-224°
沸点 701.5±70.0 °C(Predicted)
密度 1.70±0.1 g/cm3(Predicted)
酸度系数(pKa)1.44±0.10(Predicted)
磷氟康唑 用途与合成方法
生物活性Fosfluconazole是一种水溶性的fluconazole盐酸盐前体药物。Fluconazole是三唑抗真菌药物,用于治疗和组织表面的和系统性真菌感染。
靶点

Antifungal

体外研究

To investigate the polarized bioconversion and the Transwell transport of phosphate prodrugs in Caco-2 monolayer, 10 μM Fosfluconazole or Fosphenytoin is dosed either in the apical or basal compartment in Transwell plates. Both prodrugs are efficiently cleaved in the apical compartment after a 2 h incubation. To further investigate the kinetics of ALP-mediated bioconversion, the concentration-dependent ALP-mediated bioconversions are conducted to determine the Michaelis-Menten constant (K m ) of prodrug bioconversion in Caco-2 monolayers. The saturation curves of Fosphenytoin and Fosfluconazole with the concentration increase are found. The estimated K m values of Fosphenytoin and Fosfluconazole are 1160 and 357 μM, respectively.

体内研究

The apparent half-life for Fosfluconazole bioconversion in intestinal mucosa scraps is 10 min. Fluconazole (FLCZ) is an antifungal agent that is efficacious in the treatment of fungal peritonitis. Fosfluconazole (F-FLCZ) is the phosphate prodrug of FLCZ, which is highly soluble compared with FLCZ. F-FLCZ is useful against fungal peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients because it has a high water solubility. The aims of the present study are to characterize the peritoneal permeability of FLCZ and the pharmacokinetics of FLCZ and F-FLCZ after intraperitoneal (i.p.) administration to peritoneal dialysis rats. FLCZ or F-FLCZ is administered intravenously and intraperitoneally. After the i.p. administration of F-FLCZ, FLCZ is detected in circulating blood and the dialyzing fluid in peritoneal dialysis rats. The concentration of plasma FLCZ after the i.p. F-FLCZ administration is lower than that after the intravenous (i.v.) F-FLCZ administration. It is considered that the dose should be increased appropriately when F-FLCZ is administered intraperitoneally. The profiles of plasma FLCZ after i.v. and i.p. administrations are analyzed using a two-compartment model in which the distribution volume of the peripheral compartment is fixed at a volume of the dialyzing fluid (peritoneal dialysis PK model). The peritoneal dialysis PK model could describe the profiles of plasma and dialyzing fluid FLCZ. These results suggest that FLCZ and F-FLCZ could be administered intraperitoneally for the treatment of fungal peritonitis in CAPD patients.

安全信息
磷氟康唑 价格(试剂级)
更新日期产品编号产品名称CAS编号包装价格
2021/06/02S6467磷氟康唑
Fosfluconazole
194798-83-95mg794.47元
2021/06/02S6467磷氟康唑
Fosfluconazole
194798-83-925mg1392.34元
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