| Company Name: |
PharmaBlock Sciences (Nanjing),Inc.
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| Tel: |
025-86918202 4000255188 |
| Email: |
sales@pharmablock.com |
| Products Intro: |
Product Name:2-[4-(2,6-dioxo-3-piperidyl)phenoxy]acetic acid
CAS:2782024-58-0
Purity:97 Package:1G;5G;10G
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| Company Name: |
ShangHai Wisacheam Pharmaceutical Co., Ltd.
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| Tel: |
13817485796 |
| Email: |
tim@wisacheampharm.com |
| Products Intro: |
Product Name:2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid
CAS:2782024-58-0
Purity:97% Package:1G;5G;10g,25g,100g,500g
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| Company Name: |
Shanghai Xiushi Biomedical Co., LTD
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| Tel: |
15002184385 15021598081 15002184385 |
| Email: |
product001@xiushipharm.com |
| Products Intro: |
Product Name:2-[4-(2,6-Dioxo-3-piperidyl)phenoxy]acetic Acid
CAS:2782024-58-0
Purity:95 Package:10g
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| Company Name: |
Bide Pharmatech Ltd.
|
| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid
CAS:2782024-58-0
Purity:95% Package:50mg;100mg;250mg Remarks:BD01483458
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| | Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]- Basic information |
| | Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]- Chemical Properties |
| Boiling point | 538.9±50.0 °C(Predicted) | | density | 1.351±0.06 g/cm3(Predicted) | | pka | 3.15±0.10(Predicted) |
| | Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]- Usage And Synthesis |
| Uses | Phenyl-glutarimide 4 ’-oxyacetic acid is a carboxylic acid-functionalized cerebellar ligand that can be used in the development of PROTAC deactivators. Phenyl-glutarimide 4 ’-oxyacetic acid binds to PROTAC has better hydrolytic stability and efficacy[1]. | | Biological Activity | Phenyl-glutarimide 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC? Degrader development. The compound can be used to develop PG-PROTACs that exhibit improved stability to hydrolysis and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs | | IC 50 | Cereblon | | storage | Store at -20°C | | References | [1] Min J, et al. Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs. Angew Chem Int Ed Engl. 2021 Dec 13;60(51):26663-26670. DOI:10.1002/anie.202108848 |
| | Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]- Preparation Products And Raw materials |
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