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TargetMol Chemicals Inc.
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Product Name:5,6,7,8-Tetrahydro-8-deazahomofolic acid
CAS:111113-75-8
Package:25mg/RMB 13900;50mg/RMB 18300;100mg/RMB 23500
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5,6,7,8-tetrahydro-8-deazahomofolic acid manufacturers
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| | 5,6,7,8-tetrahydro-8-deazahomofolic acid Basic information |
| Product Name: | 5,6,7,8-tetrahydro-8-deazahomofolic acid | | Synonyms: | 5,6,7,8-tetrahydro-8-deazahomofolic acid;L-Glutamic acid, N-[4-[[2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido[3,2-d]pyrimidin-6-yl)ethyl]amino]benzoyl]-, (R)- (9CI);8-Tdfa;8-Tetrahydro-8-deazahomofolic acid;5,6,7,8-Tdfa;5,6,7,8 Tetrahydro 8 deazahomofolic acid,5,6,7,8Tetrahydro8deazahomofolic acid | | CAS: | 111113-75-8 | | MF: | C21H26N6O6 | | MW: | 458.47 | | EINECS: | | | Product Categories: | | | Mol File: | 111113-75-8.mol |  |
| | 5,6,7,8-tetrahydro-8-deazahomofolic acid Chemical Properties |
| density | 1.58±0.1 g/cm3(Predicted) | | pka | 3.52±0.10(Predicted) |
| | 5,6,7,8-tetrahydro-8-deazahomofolic acid Usage And Synthesis |
| Uses | 5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase[1]. | | References | [1] Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative DOI:10.1021/jm00396a022 |
| | 5,6,7,8-tetrahydro-8-deazahomofolic acid Preparation Products And Raw materials |
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