| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:E-4177;E 4177
CAS:135070-05-2
Purity:98% Package:5 mg
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| Company Name: |
CHEMICAL LAND21
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| Tel: |
82- 2 -783 - 8063 |
| Email: |
sales21@chemicalland21.com |
| Products Intro: |
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| Product Name: | E 4177 | | Synonyms: | E 4177;2-[4-[(2-cyclopropyl-7-methylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]benzoic acid | | CAS: | 135070-05-2 | | MF: | C24H21N3O2 | | MW: | 383.449 | | EINECS: | | | Product Categories: | | | Mol File: | 135070-05-2.mol |  |
| | E 4177 Chemical Properties |
| | E 4177 Usage And Synthesis |
| Description | E-4177 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. In rat adrenal cortex and liver, E4177 competitively inhibited the specific binding of 125I-[Sar1,Ile8]Ang II, with IC50 being (5.2 +/- 1.0) x 10(-8) M for the adrenal cortex and (1.2 +/- 0.3) x 10(-7) M for the liver. These IC50 values were similar to those for losartan, which showed an IC50 of (6.0 +/- 0.9) x 10(-8) M for the adrenal cortex and (1.3 +/- 0.5) x 10(-7) M for the liver. E4177 is a potent AT1 Ang II-receptor antagonist that may be clinically useful for the treatment of cardiovascular diseases such as hypertension. |
| | E 4177 Preparation Products And Raw materials |
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