| Company Name: |
Nanjing Chemlin Chemical Co., Ltd
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| Tel: |
025-83697070 |
| Email: |
info@chemlin.com.cn |
| Products Intro: |
Product Name:9-hydroxyoctadecanoic acid
CAS:3384-24-5
Purity:98% Package:1mg;5mg;50mg;500mg;5g;50g
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| | 9-hydroxystearic acid Basic information |
| | 9-hydroxystearic acid Chemical Properties |
| Melting point | 74-75 °C | | Boiling point | 433.9±28.0 °C(Predicted) | | density | 0.944±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Chloroform: soluble | | form | A solid | | pka | 4.78±0.10(Predicted) |
| | 9-hydroxystearic acid Usage And Synthesis |
| Definition | ChEBI: 9-hydroxyoctadecanoic acid is a hydroxyoctadecanoic acid that is octadecanoic acid (stearic acid) which has been substituted by a hydroxy group at position 9. It is a conjugate acid of a 9-hydroxyoctadecanoate. | | Biological Activity | 9-hydroxy Stearic acid is a hydroxy fatty acid and an active metabolite of 9-PAHSA .1,2 It is formed from 9-PAHSA by liver and pancreatic carboxyl ester lipases.2 9-hydroxy Stearic acid (5 μM) inhibits histone deacetylase 1 (HDAC1) in HT-29 colon cancer cell lysates.3 It inhibits the proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells when used at a concentration of 100 μM.1 | | References | 1.Calonghi, N., Cappadone, C., Pagnotta, E., et al.9-Hydroxystearic acid upregulates p21WAF1 in HT29 cancer cellsBiochem. Biophys. Res. Commun.314(1)138-142(2004)
2.Kolar, M.J., Kamat, S.S., Parsons, W.H., et al.Branched fatty acid esters of hydroxy fatty acids are preferred substrates of the MODY8 protein carboxyl ester lipaseBiochemistry55(33)4636-4641(2016)
3.Calonghi, N., Cappadone, C., Pagnotta, E., et al.Histone deacetylase 1: A target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancerJ. Lipid Res.46(8)1596-1603(2005) |
| | 9-hydroxystearic acid Preparation Products And Raw materials |
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