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| Product Name: | 1-EBIO | | Synonyms: | 1-Ethyl-1H-benzimidazole-2(3H)-one;1-Ethyl-2,3-dihydro-1H-benzimidazole-2-one;EBIO;1-Ethyl-2-benzimidazolinone,98%;Einecs 233-148-1;1-EB10;1-ethyl-1,3-dihydro-2H-benzimidazol-2-one(SALTDATA: FREE);1-EBIO, 1-Ethyl-2-benzimidazolinone | | CAS: | 10045-45-1 | | MF: | C9H10N2O | | MW: | 162.19 | | EINECS: | 233-148-1 | | Product Categories: | BENZIMIDAZOLE;Potassium channel;Ion Channels | | Mol File: | 10045-45-1.mol |  |
| | 1-EBIO Chemical Properties |
| Melting point | 118-120 °C(Solv: ethyl acetate (141-78-6)) | | density | 1.161±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: ≥20mg/mL | | form | powder | | pka | 12.29±0.30(Predicted) | | color | Crystalline | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Hazard Codes | Xn | | Risk Statements | 22-36 | | Safety Statements | 26 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 1-EBIO Usage And Synthesis |
| Description | 1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 μM in T84 human carcinoma cells).This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 μM).1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions. | | Uses | 1-EBIO stimulates Cl- secretion in secretory epithelia through direct activation of clacium potassium channels.
1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients | | Definition | ChEBI: 1-Ethyl-2-benzimidazolinone is a member of imidazoles. | | Biological Activity | Activator of epithelial K Ca channels, stimulates a large and sustained trans-epithelial Cl - secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. | | storage | Room temperature | | References | 1) Adeagbo?et al.?(1999),?1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol.,?379?151
2) Orfila?et al. (2014),?Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci.,?40?3179
3) Allen?et al.?(2011),?SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab.,?31?2302
4) Muller?et al. (2012),?Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev.,?8?720
5) Fay?et al.?(2006),?SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA,?103?17548 |
| | 1-EBIO Preparation Products And Raw materials |
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