| Company Name: |
Shanghai meikai technology co., ltd
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| Tel: |
021-68689288 15300790979 |
| Email: |
info@mkbio.com.cn |
| Products Intro: |
Product Name:Mipomersen(Synonyms:ISIS301012freebase)
CAS:1000120-98-8
Purity:98% Package:100mg;250mg;1g
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| | mipomersen Basic information |
| Product Name: | mipomersen | | Synonyms: | mipomersen;ISIS 301012 Parent Acid;Mipomersen(Synonyms:ISIS301012freebase) | | CAS: | 1000120-98-8 | | MF: | C230H324N67O122P19S19 | | MW: | 7177.145719 | | EINECS: | | | Product Categories: | | | Mol File: | 1000120-98-8.mol |  |
| | mipomersen Chemical Properties |
| form | Solid | | color | White to off-white |
| | mipomersen Usage And Synthesis |
| Uses | Mipomersen (ISIS 301012 free base) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen can be used for the research of homozygous familial hypercholesterolemia (HoFH)[1][2]. | | in vivo | Mipomersen (25 mg/kg; i.p., twice weekly for 11 weeks) affects levels of h-apoB, h-apoB-100, Lp(a) and OxPL/h-apoB[1]. | Animal Model: | Transgenic mice overexpressing human apolipoprotein B-100 (h-apoB mice) or h-apoB-100 plus human apo(a) (Lp(a) mice)[1] | | Dosage: | 25 mg/kg | | Administration: | Intraperitoneal injection; 25 mg/kg, twice weekly for 11 weeks | | Result: | Time-dependently reduced the level of h-apoB-100 in Lp(a) mice and h-apoB in h-apoB mice. |
| | IC 50 | apoB | | References | [1] Merki E, et al. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 2008 Aug 12;118(7):743-53. DOI:10.1161/CIRCULATIONAHA.108.786822
[2] Schaefer EA, et al. Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C. World J Gastroenterol. 2016 Dec 7;22(45):9954-9965. DOI:10.3748/wjg.v22.i45.9954 |
| | mipomersen Preparation Products And Raw materials |
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