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| | Picotamide Basic information |
| Product Name: | Picotamide | | Synonyms: | 4-METHOXY-N,N'-BIS(3-PYRIDINYLMETHYL)-1,3-BENZENEDICARBOXAMIDE;PICOTAMIDE;4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid;4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide;g137;n,n’-bis(3-picolyl)-4-methoxyisophthalamide;n,n’-bis(3-pyridinylmethyl)-4-methoxy-1,3-benzenedicarboxamide;n,n’-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide | | CAS: | 32828-81-2 | | MF: | C21H20N4O3 | | MW: | 376.41 | | EINECS: | 251-245-7 | | Product Categories: | | | Mol File: | 32828-81-2.mol |  |
| | Picotamide Chemical Properties |
| Melting point | 128-131℃ | | Boiling point | 668.1±55.0 °C(Predicted) | | density | 1.246±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming). | | pka | 13.31±0.46(Predicted) | | form | White solid. | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| WGK Germany | 2 | | RTECS | CZ2235500 | | Toxicity | LD50 i.p. in male mice: 1205 mg/kg (Orzalesi, Selleri, 1976) |
| | Picotamide Usage And Synthesis |
| Description | Picotamide is an unique antithrombotic agent which acts by selectively inhibiting
thromboxane synthesis and blocking platelet thromboxane receptors without affecting
prostaglandin synthesis. It is reported to be useful in the treatment of myocardial
infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis. | | Originator | Manetti-Roberts (Beecham (Italy) | | Uses | Keratolytic. | | Uses | Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase. It is used in aptamers for targeting coagulation factor XIII and there used for treatment of thrombosis. | | Definition | ChEBI: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide is a member of benzamides. | | Brand name | Plactidil | | References | Modesti, et al. (1989), Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide; Eur. J. Pharmacol.. 169 85
Modesti, et al. (1991), Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 inhibitor; Br. J. Pharmacol.. 31 439
Ratti et al. (1998), Picotamide, an antithromboxane agent. Inhibits the migration and proliferation of arterial myocytes; Eur. J. Pharmacol. 355 77 |
| | Picotamide Preparation Products And Raw materials |
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