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Leuprorelin acetate

Leuprorelin acetate Suppliers list
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
Products Intro: Product Name:Leuprorelin acetate
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:74381-53-6
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;
Products Intro: CAS:74381-53-6
Package:g-Kg Remarks:White powder
Tel: +86 21 5161 9050/ 5187 7795
Products Intro: Product Name:Leuprorelin Acetate
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:Leuprorelin acetate
CAS: 74381-53-6
Purity:99% Package:1KG;7USD

Lastest Price from Leuprorelin acetate manufacturers

  • Leuprorelin acetate
  • US $7.00 / KG
  • 2019-09-02
  • CAS: 74381-53-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100KG
Leuprorelin acetate Basic information
Anti-cancer drugs
Product Name:Leuprorelin acetate
Synonyms:leutenizinghormone-releasingfactor(pig),6-d-leucine-9-(n-ethyl-l-prolinamid;lupron;tap-144;6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing Hormone-Releasing Factor Acetate(Pig);Abbott 43818;Procren Depot;Procrin;Prostap
Product Categories:Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Gonadotropin-releasing hormone (GnRH);Anti-cancer&immunity;Organics
Mol File:74381-53-6.mol
Leuprorelin acetate Structure
Leuprorelin acetate Chemical Properties
Melting point 150-155°C
storage temp. −20°C
Merck 14,5457
Safety Information
Safety Statements 22-24/25
WGK Germany 2
RTECS OH6390000
HS Code 29371900
MSDS Information
SigmaAldrich English
Leuprorelin acetate Usage And Synthesis
Anti-cancer drugsLeuprolide acetate is a commonly used hormone anti-cancer drug, , it is a acetate of leuprolide which is a nonapeptide synthetic analogue of LHRH( one kind decapeptide), it is a LH-RH antagonist, LHRH is produced by the hypothalamus, it can promote pituitary for the release of gonadotropins and follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This product’s structure is similar to LHRH, its acting on the anterior pituitary which prompts FSH, LH release function, increases serum concentrations of testosterone and dihydro testosterone. It is used as maintenance therapy for advanced prostate cancer clinically, but in about one week after use of the product, the number of active receptors will be reduced, and gonadotropin secretion will be reduced.After 2 to 4 weeks, the concentration of testosterone and dihydro testosterone can be reduced to castration levels. After the withdrawal, gonadotropin and androgen concentrations can be recovered to normal.
Note that this product is not effective when administered orally, subcutaneous or intramuscular administration has good absorption. T1/2 of parenteral administration is 3 h. There is no accumulation in the body, unchanged drugs and its metabolites in urine excretion rates are2.9% and 1.5%, respectively. Ethanol can enhance the role of this product, the course of treatment should not drink, in case it is difficult to control the incidence of adverse reactions. In the first week of the course of treatment ,patients should try to be hospitalized for monitoring, choose an experienced physician to guide treatment to prevent severe neurological complications, urinary tract obstruction. Injection site should often vary.
The above information is edited by the chemicalbook of Tian Ye.
DescriptionLeuprolide acetate is a potent analog of LH-RH useful in achieving a medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of advanced breast cancer.
Chemical PropertiesFluffy Solid
OriginatorTakeda (Japan)
UsesSynthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).
DefinitionChEBI: An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the t eatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Brand nameEligard (QLT); Lupron(TAP); Viadur (ALZA);CARCINIL.
Leuprorelin acetate Preparation Products And Raw materials
Tag:Leuprorelin acetate(74381-53-6) Related Product Information
Acetic acid Ammonium acetate Vinyl acetate Ethyl acetate Magnesium acetate Sodium acetate Calcium acetate Goserelin acetate ACETATE CELLULOSE ACETATE cellulore Benzyl acetate Leuprorelin acetate Leuprorelin Sodium acetate trihydrate Butyl acetate