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4-Bromophenol

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CAS:106-41-2
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CAS:106-41-2
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4-Bromophenol manufacturers

  • P-Bromophenol
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  • $0.00 / 200kg
  • 2025-02-05
  • CAS:106-41-2
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  • Purity: 99%
  • Supply Ability: 20 tons
  • 4-Bromophenol
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  • 2024-10-24
  • CAS:106-41-2
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  • 4-Bromophenol
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  • 2024-10-11
  • CAS:106-41-2
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4-Bromophenol Basic information
Product Name:4-Bromophenol
Synonyms:BROMOPHENOL-4;4-BROMOHYDROXYBENZENE;4-Bromophenol p-Bromophenol;4-BROMOPHENOL;AKOS BBS-00004402;4-Bromophbenol;4-Bromophenoles;p-Bromophenoles
CAS:106-41-2
MF:C6H5BrO
MW:173.01
EINECS:203-394-4
Product Categories:intermediates;alcohol| alkyl bromide;Bromo;Halogenated;Volatiles/ Semivolatiles;Building Blocks for Liquid Crystals;Functional Materials;Phenols (Building Blocks for Liquid Crystals);Phenyls & Phenyl-Het;Aromatic Phenols;Halides;Phenyls & Phenyl-Het;Heterocyclic Compounds;A-BAlphabetic;Alpha Sort;B;BI - BZChemical Class;Organic Building Blocks;Oxygen Compounds;Phenols
Mol File:106-41-2.mol
4-Bromophenol Structure
4-Bromophenol Chemical Properties
Melting point 61-64 °C (lit.)
Boiling point 235-236 °C (lit.)
density 1.84
refractive index 1.5085 (estimate)
Fp 235-238°C
storage temp. room temp
solubility 14g/l
form Crystalline Solid
pka9.37(at 25℃)
color Pinkish-brown
Water Solubility It is insoluble in water. It is soluble in 5%ethanol.
λmax282nm(EtOH)(lit.)
Merck 14,1428
BRN 1680024
CAS DataBase Reference106-41-2(CAS DataBase Reference)
NIST Chemistry Reference4-Bromophenol(106-41-2)
EPA Substance Registry SystemPhenol, 4-bromo- (106-41-2)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38-20/21/22
Safety Statements 26-37/39-36
RIDADR 2811
WGK Germany 2
RTECS SJ7960000
8-10-23
Hazard Note Irritant
TSCA Yes
HazardClass 6.1(b)
PackingGroup III
HS Code 29081000
Hazardous Substances Data106-41-2(Hazardous Substances Data)
Toxicitymouse,LD50,intraperitoneal,411mg/kg (411mg/kg),Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(12), Pg. 19, 1979.
MSDS Information
ProviderLanguage
4-Bromophenol English
SigmaAldrich English
ACROS English
ALFA English
4-Bromophenol Usage And Synthesis
Chemical Properties4-Bromophenol is a pinkish-brown crystalline solid. four-sided biconical crystal precipitated from ether or chloroform. The melting point is 66.4 ℃, and a small amount of water can reduce the melting point a lot. Soluble in water, chloroform, easily soluble in ethanol, ether and glacial acetic acid, soluble in 7 parts of water.
Uses4-Bromophenol is used as an intermediate in medicine grade. It is also used as a phenol that is used in Stille reactions. It is used in the intermediate of organic synthesis, flame retardant and pharmaceutical industry.
Application4-Bromophenol is a phenolic derivative that It can used as a reagent in Stille reactions or Intermediates of Liquid Crystals.
Preparation4-Bromophenol is synthesized by bromination of phenol. The bromine and carbon disulfide solution was added to the phenolic carbon disulfide solution, and the addition was started below 5°C, and the addition was completed under stirring for 2 hours. Phenol and bromine are approximately equimolar ingredients. Distill the reactant to remove carbon disulfide, and then conduct fractional distillation under reduced pressure to collect fractions at 145-150°C (3.32-3.99kPa) to obtain the product. Yield 80-84%.
DefinitionChEBI: 4-bromophenol is a bromophenol containing only hydroxy and bromo substituents that are para to one another. It has a role as a mouse metabolite, a persistent organic pollutant, a human xenobiotic metabolite, a rat metabolite, a human urinary metabolite and a marine metabolite.
Synthesis Reference(s)Tetrahedron, 45, p. 7869, 1989 DOI: 10.1016/S0040-4020(01)85800-2
The Journal of Organic Chemistry, 23, p. 280, 1958 DOI: 10.1021/jo01096a033
Synthesis m-Bromoaniline (50 g) is dissolved by boiling in a mixture of water (400 ml) and sulfuric acid (50 ml). The solution is then cooled to 10℃ and diazotized by the addition of sodium nitrite (21 g) dissolved in a small amount of water, The resulting diazonium salt solution is run in a thin stream during fifteen to thirty minutes into a boiling mixture of water (300 ml) and sulfuric acid (100 ml) contained in a flask fitted with a dropping funnel, a steam inlet tube reaching to the bottom of the flask, and an efficient condenser set for downward distillation. During the addition of the diazonium salt solution the acid solution is heated so that its volume remains constant, and steam is passed in at such a rate that at the end of the addition approximately 1 liter of distillate has been collected. Steam distillation is then continued until 2-liters of distillate has been collected. To this is added sodium chloride (150 g), and the phenol is extracted with ether, using portions of 200, 100, and 100 ml. The ether is removed from the combined extracts and the product is distilled under reduced pressure. Eight runs of 50 g, each of m-bromoaniline gave 330 g of crude m-bromophenol boiling at 100-140℃ (20-30 mm.). Redistillation gave 313 g (77.8%) of m-bromophenol which boiled at 125-130℃ at 25 mm. Treatment of this 313 g of product with sodium hydroxide and methyl sulfate gave 285 g of m-bromoanisole (4-bromophenol), b. p. 100℃ at 20 mm[1].
Purification MethodsCrystallise the phenol from CHCl3, CCl4, pet ether (b 40-60o), or water and dry it at 70o under vacuum for 2hours. [Beilstein 6 IV 1043.]
References[1] Koelsch, C. Frederick. “The Preparation of m-Bromophenol.” Journal of the American Chemical Society 61 4 (1939): 969.
Tag:4-Bromophenol(106-41-2) Related Product Information
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