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Acitretin Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Products Intro: Product Name:Acitretin
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Products Intro: Product Name:Acitretin
Purity:99% Package:25300/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Acitretin
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Products Intro: Product Name:Acitretin
Purity:99% Package:1Kg;25kg/ Drum or as customer request
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:55079-83-9
Purity:99% Package:500G;1KG;5KG;25KG

Lastest Price from Acitretin manufacturers

  • Acitretin
  • US $7.00 / KG
  • 2019-07-06
  • CAS: 55079-83-9
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000KG
  • Acitretin
  • US $1.00 / KG
  • 2019-07-06
  • CAS:55079-83-9
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 100KG
Acitretin Basic information
Product Name:Acitretin
Synonyms:6,8-nonatetraenoicacid,3,7-dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-4;all-trans-3,7-dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetra;all-trans-etretin;retinoidetretin;ro10-1670;(E)-9-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-3,7-DIMETHYL-2,4,6,8-NONATETRAENOIC ACID;Huh-7.5.1 Cell;(all-e)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraen
Product Categories:-;Inhibitors;Active Pharmaceutical Ingredients;Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Retinoids;Intracellular receptor;API;Aromatics;Soriatane
Mol File:55079-83-9.mol
Acitretin Structure
Acitretin Chemical Properties
Melting point 228-230°C
Boiling point 404.46°C (rough estimate)
density 1.1348 (rough estimate)
refractive index 1.4700 (estimate)
storage temp. 2-8°C
solubility Practically insoluble in water, sparingly soluble in tetrahydrofuran, slightly soluble in acetone and in ethanol (96 per cent), very slightly soluble in cyclohexane.
form powder
Merck 14,112
CAS DataBase Reference55079-83-9(CAS DataBase Reference)
Safety Information
Hazard Codes T,N
Risk Statements 61-36/38-50/53
Safety Statements 53-26-45-60-61-37/39
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS RA8460000
HazardClass 9
PackingGroup III
Hazardous Substances Data55079-83-9(Hazardous Substances Data)
ToxicityLD50 i.p. in mice (mg/kg): >4000 (1 day), 700 (10 days), 700 (20 days) (Bollag, 1978)
MSDS Information
Etretin English
SigmaAldrich English
Acitretin Usage And Synthesis
DescriptionAcitretin is the free acid form of etretinate useful in the treatment of severe psoriasis and other disorders of keratinization. Although the two compounds have virtually the same efficacy and teratogenic side-effects, acitretin is advantageous for child-bearing women, as its shorter half-life reduces the necessary contraception period from two years to only one month after treatment ceases.
Chemical PropertiesCrystalline Solid
OriginatorHoffmann-La Roche (Switzerland)
UsesA synthetic retinoid which is the major metabolite of etretinate (E938000).
Usesantipsoriatic;binds to nuclear receptors that regulate gene transcription
IndicationsUnlike isotretinoin, acitretin (Soriatane) is not primarily sebosuppressive. Rather, it promotes normalization of dysregulated keratinocyte proliferative activity in the epidermis and is also antiinflammatory. Oral absorption is optimal when acitretin is taken with a fatty meal; peak levels are reached approximately 3 hours after ingestion, while steady-state plasma levels are achieved after approximately 3 weeks of daily dosing. The mean terminal elimination half-life of the parent compound is 49 hours. However, when consumed with ethanol, acitretin may be transesterified to form etretinate, a retinoid that is stored in adipose tissue, resulting in a much longer half-life (3–4 months or longer).
Brand nameSoriatane (Connetics);Neotigason (r) 10;Neotigason roche 10 mg;Neotigason sauter kapsein 25 mg.
World Health Organization (WHO)Acitretin, a retinol derivative, was introduced in 1989 for the treatment of severe psoriasis. By the end of 1990, acitretin was confirmed to be metabolized in part to etretinate. Marketing authorization was suspended temporarily in France while the product information was modified to conform to the recommendations issued by the Committee for Proprietary Medicinal Products of the European Communities. Acitretin remains registered in several countries. See also WHO comment for etretinate.
PharmacologyLike other systemic retinoids, acitretin is a serious teratogen and should not be prescribed for women of childbearing potential unless no acceptable alternative is available and the patient has acknowledged in writing that she understands the need to use two effective forms of contraception during therapy and for 3 years following discontinuation of therapy. Because of the much longer half-life of etretinate, which may be formed when ethanol is ingested with acitretin, female patients of childbearing potential must also agree not to ingest alcohol during treatment and for 2 months following its discontinuation. Other toxicities are similar to those of isotretinoin; they include cutaneous irritation and inflammation, bone and joint pain, hyperlipidemia, hepatic enzyme elevation, and tendinous and ligamentous calcifications.Alopecia (hair loss) may also occur in some patients.
Clinical UseAcitretin is most useful for the treatment of severe psoriasis, particularly the pustular and erythrodermic variants. Psoriatic nail changes and arthritis also may respond. Combining the drug with ultraviolet light therapy (Re-UVB, in the case of ultraviolet B radiation, or Re-PUVA, with psoralen plus ultraviolet A radiation) permits the use of lower doses of both acitretin and ultraviolet radiation. Other conditions for which the drug may be especially useful include congenital and acquired hyperkeratotic disorders, such as the ichthyoses and palmoplantar keratodermas, and severe lichen planus.
Veterinary Drugs and TreatmentsAcitretin may be useful in the treatment of canine lamellar ichthyosis, solar-induced precancerous lesions in Dalmatians or bull Terriers, actinic keratoses, squamous cell carcinomas, and intracutaneous cornifying epitheliomas (multiple keratoacanthomas).
While the drug has provided effective treatment of idiopathic seborrhea (particularly in cocker spaniels), it is not effective in treating the ceruminous otitis that may also be present. Results have been disappointing in treating idiopathic seborrheas seen in basset hounds and West Highland terriers.
Acitretin’s usage in cats is very limited, but etretinate has shown some usefulness in treating paraneoplastic actinic keratosis, solarinduced squamous cell carcinoma and Bowen’s Disease in this species.
Enzyme inhibitorThis orally active, synthetic retinoid (FW = 326.43 g/mol; CAS 55079-83-9), systematically named as (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid, inhibits calcineurin, weakly, retinol dehydrogenase, retinyl-palmitate esterase, and ribonuclease P. Acitretin is used to treat psoriasis by binding to nuclear receptors regulating gene transcription and inducing keratinocyte differentiation, thereby reducing epidermal hyperplasia,
Acitretin Preparation Products And Raw materials
Raw materialsTriethyl orthoformate-->Phosphorous acid-->Ethoxyethyne-->TOLUALDEHYDES-->THREE METHYL BENZENE
Tag:Acitretin(55079-83-9) Related Product Information
Adenine 4-Methoxyphenylacetone Dimethicone Acitretin Dimethyl sulfoxide N,N-Dimethylformamide Dimethyl sebacate N,N-Dimethylacetamide Retinoic acid 2,4,6,8-DECATETRAENOIC ACID ALL-TRANS ACITRETIN-D3 (2E,4E,6E,8E)-9-(4-METHOXY-2,3,6-TRIMETHYL-PHENYL)-3,7-DIMETHYL-NONA-2,4,6,8-TETRAENOIC ACID BUTYL ESTER Methoxy Acitretin ethyl ester Poly(dimethylsiloxane) Abamectin Isotretinoin Dimethyl sulfone