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4'-Hydroxyacetophenone

4'-Hydroxyacetophenone Suppliers list
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Products Intro: Product Name:4'-Hydroxyacetophenone; 1-(4-Hydroxyphenyl)ethanone; 4-Acetylphenol; p-Hydroxyacetophenone
CAS:99-93-4
Purity:99%; 99.9% Package:25KG;USD
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Products Intro: Product Name:p-Hydroxyacetophenone
CAS:99-93-4
Purity:99% Package:1KG;20USD
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Products Intro: Product Name:4'-hydroxyacetophenone
CAS:99-93-4
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Products Intro: Product Name:4'-Hydroxyacetophenone
CAS:99-93-4
Purity:99% Package:100g ,1KG ,5KG 25KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:4'-Hydroxyacetophenone
CAS:99-93-4
Purity:98%99% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG

4'-Hydroxyacetophenone manufacturers

4'-Hydroxyacetophenone Basic information
Product Name:4'-Hydroxyacetophenone
Synonyms:1-(4-hydroxyphenyl)-ethanon;4’-hydroxy-acetophenon;4-Hydroksyacetofenol;Acetophenone, p-hydroxy-;Ethanone, 1-(4-hydroxyphenyl)-;Hydroxyacetophenone, para;HYDROXYACETOPHENONE-4;HYDROXYBENZOPHENONE-4
CAS:99-93-4
MF:C8H8O2
MW:136.15
EINECS:202-802-8
Product Categories:Pyridines;Pharmaceutical intermediates for Choleretic and Salbutamol;Aromatic Acetophenones & Derivatives (substituted);Aromatics;Miscellaneous Reagents;Eczema, medicine and other organic synthesis intermediates;Acetophenone Series;FINE Chemical & INTERMEDIATES;AcetophenoneCarbonyl Compounds;C7 to C8;Ketones;Organic Photoinitiators;Polymerization Initiators;Carbonyl Compounds;VX:15689727968
Mol File:99-93-4.mol
4'-Hydroxyacetophenone Structure
4'-Hydroxyacetophenone Chemical Properties
Melting point 132-135 °C(lit.)
Boiling point 147-148 °C3 mm Hg(lit.)
density 1.109
refractive index 1.5577 (estimate)
FEMA 4330 | 4-HYDROXYACETOPHENONE
Fp 166 °C
storage temp. Store below +30°C.
solubility methanol: 0.1 g/mL, clear
form Crystalline Powder
pka8.05(at 25℃)
color Almost white to beige
Specific Gravity1.109
Water Solubility 10 g/L (22 ºC)
JECFA Number2040
BRN 774355
InChIKeyTXFPEBPIARQUIG-UHFFFAOYSA-N
CAS DataBase Reference99-93-4(CAS DataBase Reference)
NIST Chemistry ReferenceAcetophenone, 4'-hydroxy-(99-93-4)
EPA Substance Registry System4-Hydroxyacetophenone (99-93-4)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 36/37/38-22
Safety Statements 26-36/37-37/39-24/25-22-36
WGK Germany 3
RTECS PC4959775
Hazard Note Irritant
TSCA Yes
HS Code 29145000
MSDS Information
ProviderLanguage
1-(4-Hydroxyphenyl)ethanone English
SigmaAldrich English
ACROS English
ALFA English
4'-Hydroxyacetophenone Usage And Synthesis
Chemical Propertiesalmost white to beige crystalline powder
Chemical PropertiesWhite to beige powder; sweet, hawthorn, balsam, mimosa aroma
OccurrenceReported found in cloudberry, coffee, cranberry, mango, sherry, and wort.
Uses4?-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.
PreparationPreparation by Fries rearrangement of phenyl acetate with Lewis acids
aluminium chloride
in nitrobenzene at 20–25° or at 50–60°
in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%)
in nitroethane at 60° (44%)
in carbon disulfide at 45° (40%)
in petroleum ether at 50° (20%)
but between 130° and 175° (40–60%)
aluminium chloride–sodium chloride mixture at 240–250° (10%)
boron trifluoride at 90° (56%)
scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%)
titanium tetrachloride at 90–100° (34%)
ferric chloride at 65° (25%)
zinc chloride at 125° (8%)
hydrofluoric acid, between 20° and 100° (94%)
polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%)
Nafion-XR 500, sulfonic acid type at 100°
ZSM-5, in sulfolane, at 180° (28%)
H-ZSM-5 at 400° or at 210° (6%)
H-Nu-2 at 170° (15%)
HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°.
DefinitionChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.
Aroma threshold valuesFloral type, medium strength odor; recommend smelling in a 10.00% solution or less.
Synthesis Reference(s)Tetrahedron Letters, 32, p. 5829, 1991 DOI: 10.1016/S0040-4039(00)93567-6
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Purification MethodsCrystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]
Tag:4'-Hydroxyacetophenone(99-93-4) Related Product Information
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