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VALINOMYCIN

VALINOMYCIN Suppliers list
Company Name: career henan chemical co
Tel: +86-0371-55982848
Email: sales@coreychem.com
Products Intro: Product Name:Valinomycin
CAS:2001-95-8
Purity:99% Package:1KG;1USD
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +8619930503282
Email: sales3@crovellbio.com
Products Intro: Product Name:VALINOMYCIN
CAS:2001-95-8
Purity:99% Package:1PCS;1USD
Company Name: Chongqing Chemdad Co.,Ltd
Tel: +86-19923101450
Email: sales@chemdad.com
Products Intro: Product Name:VALINOMYCIN
CAS:2001-95-8
Package:1kg,2kg,5kg,10kg,25kg
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:VALINOMYCIN
CAS:2001-95-8
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: Product Name:バリノマイシン
CAS:2001-95-8
Purity:0.99 Package:5KG;1KG;7410KG

VALINOMYCIN manufacturers

  • VALINOMYCIN USP/EP/BP
  • $1.10 / g
  • 2021-06-24
  • CAS:2001-95-8
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
  • VALINOMYCIN
  • $1.00 / PCS
  • 2021-05-25
  • CAS:2001-95-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10 mt
  • Valinomycin
  • $1.00 / KG
  • 2020-05-08
  • CAS: 2001-95-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20T
VALINOMYCIN Basic information
Product Name:VALINOMYCIN
Synonyms:1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,;14,17,20,23,26,29,32,35-dodecone,12,24,36-trimetyl-3,6,9,15,18,21,27,30,33-non;akis(1-methylethyl)-[qr];Valinomycin, ≥98%(TLC),≥95%(HPLC),solid;Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem;aleryl-d-valyl-l-lactoyl-l-valyl-d-alpha-hydroxyisovaleryl-d-valyl-l-lactoyl-l;antibioticn-329b;cyclic(d-alpha-hydroxyisovaleryl-d-valyl-l-lactoyl-l-valyl-d-alpha-hydroxyisov
CAS:2001-95-8
MF:C54H90N6O18
MW:1111.32
EINECS:217-896-6
Product Categories:antibiotic;Agro-Products;Inhibitors;Peptides
Mol File:2001-95-8.mol
VALINOMYCIN Structure
VALINOMYCIN Chemical Properties
Melting point 187-190 °C
alpha D20 +31.0° (c = 1.6 in benzene)
Boiling point 821.74°C (rough estimate)
density 1.060
refractive index 1.6400 (estimate)
Fp 87℃
storage temp. 2-8°C
solubility DMSO: ≥10 mg/mL
form solid
pka11.32±0.70(Predicted)
color white
optical activity[α]20/D +32±2°, c = 1.6% in benzene
Water Solubility Soluble in DMSO at 10mg/ml. Insoluble in water
Merck 13,9976
BRN 78657
EPA Substance Registry SystemValinomycin (2001-95-8)
Safety Information
Hazard Codes Xn,T,T+,Xi
Risk Statements 27/28-36/37/38-21/22
Safety Statements 36-45-36/37-28-37/39-26
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS YV9468000
10-18-21
TSCA Yes
HazardClass 6.1(a)
PackingGroup I
HS Code 29419090
Hazardous Substances Data2001-95-8(Hazardous Substances Data)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
VALINOMYCIN Usage And Synthesis
Chemical Propertieswhite crystalline powder
UsesInsecticide, nematocide, Patterson, Wright, US 3520973 (1970 to Am. Cyanamid).
Usesantibiotic; LD50 (rat, po) 4 mg/kg
UsesK+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and anta gonizes ET-induced vasoconstriction. Used as insecticide, nematocide.
UsesValinomycin is a hydrophobic cyclodepsipeptide with potent antitumour activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.
UsesValinomycin is a hydrophobic cyclodepsipeptide with potent antitumor activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.
DefinitionChEBI: A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in severa Streptomyces strains.
General DescriptionShiny crystalline solid. Used as an insecticide and nematocide. Not registered as a pesticide in the U.S.
Reactivity ProfileVALINOMYCIN is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health HazardVALINOMYCIN is highly toxic orally.
Fire HazardWhen heated to decomposition, VALINOMYCIN emits toxic fumes of nitrogen oxides.
Biological ActivitySelective K + ionophore (K 0.5 values are 48, 73, 75, 93 and 246 mM for K + , Rb + , Cs + , Na + and Li + respectively) that transports K + across biological and artificial lipid membranes. Inhibits Ca 2+ -ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro .
Biochem/physiol ActionsValinomycin affects the ion transport behavior of mitochondrial systems.
Purification MethodsRecrystallise valinomycin from dibutyl ether or Et2O. It is dimorphic: modification A crystallises from n-octane, and modification B crystallises from EtOH/H2O. It is soluble in pet ether, CHCl3, AcOH, BuOAc and Me2CO. [Smith et al. J Am Chem Soc 97 7242 1975, UV, IR and NMR see Brocknmann & Schmidt-Kastner Chem Ber 88 57 1955, Beilstein 27 I 9728. 17 IV 9728.]
VALINOMYCIN Preparation Products And Raw materials
Tag:VALINOMYCIN(2001-95-8) Related Product Information
2-HYDROXYACETAMIDE (S)-(+)-1-METHOXY-2-PROPYLAMINE N-SEC-BUTYL-N-PROPYLAMINE (1,2-DIMETHYLPROPYL)METHYLAMINE 1,5-DIAMINO-3-OXAPENTANE N-ME-DL-VAL-OH HCL N-(2-BUTYL)PROPANAMIDE 1-AMINO-2-BUTANOL AC-ALA-OME 2-Isopropoxy-ethylamine (R)-(-)-2-Amino-3-methyl-1-butanol Propyl butyrate Isobutyl isovalerate Isobutyl butyrate 2-ACETAMIDOPROPIONIC ACID METHYL ESTER Ethyl acetamidoacetate AC-VAL-OME ETHOXYACETALDEHYDE