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Monoethyl fumarate

Monoethyl fumarate Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Email: sales@capotchem.com
Products Intro: Product Name:Monoethyl fumarate
CAS:2459-05-4
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Monoethyl fumarate
CAS:2459-05-4
Purity:99% Package:1kg;1USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:Monoethyl fumarate
CAS:2459-05-4
Purity:99% Package:5KG;1KG Remarks:C6H8O4
Company Name: Haihang Industry Co.,Ltd
Tel: 86-531-88032799
Email: export@haihangchem.com
Products Intro: CAS:2459-05-4
Package:5KG;1KG
Company Name: QUALITY CONTROL CHEMICALS INC.
Tel: (323) 306-3136
Email: orders@qcchemical.com
Products Intro: Product Name:Quetiapine EP Impurity R
CAS:2459-05-4
Purity:95% Package:10mg;25mg;50mg;100mg;250mg Remarks:Brand: QCC CAT#QQ201617

Lastest Price from Monoethyl fumarate manufacturers

  • Monoethyl fumarate
  • US $1.00 / KG
  • 2020-01-03
  • CAS: 2459-05-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20T
  • Monoethyl fumarate
  • US $1.00 / kg
  • 2019-07-06
  • CAS:2459-05-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: Customized
Monoethyl fumarate Basic information
Description References
Product Name:Monoethyl fumarate
Synonyms:(2E)-4-Ethoxy-4-oxo-2-butenoic acid;2-Butenedioic acid (E)-, monoethyl ester;(2E)-2-Butenedioic Acid Monoethyl Ester;FuMaric Acid Ethyl Ester;Monoethyl FuMerate;Monoethyl trans-2-Butenedioate;Ethyl Hydrogen Fumarate Fumaric Acid Monoethyl Ester;Monoethyl FuMarate (Quetiapine IMpurity R)
CAS:2459-05-4
MF:C6H8O4
MW:144.13
EINECS:219-544-7
Product Categories:Building Blocks;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks;mildew preventive
Mol File:2459-05-4.mol
Monoethyl fumarate Structure
Monoethyl fumarate Chemical Properties
Melting point 66-68 °C(lit.)
Boiling point 147 °C16 mm Hg(lit.)
density 1.1109
refractive index 1.4500 (estimate)
storage temp. Refrigerator
form Crystalline Powder
pka3.45±0.10(Predicted)
color Almost white to beige
Water Solubility Soluble in water.
BRN 1723588
CAS DataBase Reference2459-05-4(CAS DataBase Reference)
NIST Chemistry ReferenceEthyl hydrogen fumarate(2459-05-4)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 1
HazardClass IRRITANT
HS Code 29171900
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Monoethyl fumarate Usage And Synthesis
DescriptionMonoethyl fumarate is the Monoethyl ester form of fumarate. It is a kind of effective preservative and polymerization agent for macromolecular material. Monoethyl fumarate is capable of inhibiting the growth of bacteria, yeast and mold and prolonging the storage time of feed can. It can also be used for long-term systemic therapy in the treatment of psoriasis (a chronic hyperproliferative inflammatory skin disorder). It is the most active ingredient in the antipsoriasis drug Fumadem. The mechanism is likely to be related to its effect of improvement of keratinocyte differentiation and inhibition of keratinocyte proliferation. Monomethyl fumarate has beneficial effects on the inflamed blood–brain barrier. It increases levels of endogenous antioxidant proteins in brain endothelial cells and reduces expression of VCAM-1 in inflamed brain endothelial cells. Transendothelial monocyte migration is limited upon MMF treatment.
ReferencesThio, H. B., et al. "Long‐term systemic therapy with dimethylfumarate and monoethylfumarate (Fumaderm®;) in psoriasis." Journal of the European Academy of Dermatology & Venereology 4.1(1995):35-40.
Asadullah, K, et al. "Influence of monomethylfumarate on monocytic cytokine formation--explanation for adverse and therapeutic effects in psoriasis?." Archives of Dermatological Research 289.11(1997):623-30.
Lim, J. L., et al. "Protective effects of monomethyl fumarate at the inflamed blood-brain barrier." Microvascular Research 105(2016):61.
Zhao, Wen Xiu, C. M. Zhang, and X. U. Xue-Ming. "Synthesis and antimicrobial active of monomethyl fumarate." Science & Technology of Food Industry (2008).
Helwa, Inas. "The Mechanism of Monomethylfumarate (MMF) as an Anti-psoriatic Agent." Helwa Inas (2014)
Chemical PropertiesALMOST WHITE TO BEIGE CRYSTALLINE POWDER
Monoethyl fumarate Preparation Products And Raw materials
Tag:Monoethyl fumarate(2459-05-4) Related Product Information
FUMARIC ACID MONOETHYL ESTER, ZINC SALT FUMARIC ACID MONOETHYL ESTER, MAGNESIUM SALT Diethyl oxalacetate sodium salt BIS(HEXAFLUOROISOPROPYL)MALEATE DIETHYL DICYANOFUMARATE, 97 DIPENTYL FUMARATE FUMARPROTOCETRARIC ACID DIALLYL FUMARATE FUMARIC ACID MONOETHYL ESTER, CALCIUM SALT Diethyl oxalacetate Monoethyl fumarate Diethyl fumarate Dimethyl fumarate MONO-ETHYL SUCCINATE Ferrous fumarate BUTYL OLEATE FUMARATE Fumaric acid