- N-Boc-1,3-propanediamine
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- $5.00 / 200kg
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2026-01-23
- CAS:75178-96-0
- Min. Order: 1kg
- Purity: ≥98%
- Supply Ability: 100mt/year
- N-Boc-1,3-propanediamine
-
- $0.00 / 1KG
-
2026-01-23
- CAS:75178-96-0
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
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| | N-Boc-1,3-propanediamine Basic information |
| Product Name: | N-Boc-1,3-propanediamine | | Synonyms: | N-(3-Aminopropyl)carbamic acid tert-butyl ester ,85%;tert-butyl (3-aminopropyl)carbamate(SALTDATA: FREE);Propane-1,3-diamine, N-BOC protected;1,3-Diaminopropane, N-BOC protected, tert-Butyl (3-aminoprop-1-yl)carbamate;N-Boc-1,3-diaminopropane, tert-Butyl N-(3-aminopropyl)carbamate;tert-Butyl N-(3-aMinopropyl)ca;N-(TERT-BUTOXYCARBONYL)-1,3-DIAMINOPROPANE;N-(TERT-BUTOXYCARBONYL)-1,3-PROPANEDIAMINE | | CAS: | 75178-96-0 | | MF: | C8H18N2O2 | | MW: | 174.24 | | EINECS: | 628-600-3 | | Product Categories: | Amines and Anilines;N-BOC;Monoprotected Diaminoalkanes;N-Boc-diaminoalkanes;Bifunctional Linkers;Building Blocks;Chemical Biology;Chemical Synthesis;Linkers and Crosslinkers;Nitrogen Compounds;Organic Building Blocks;Protected Amines;pharmacetical | | Mol File: | 75178-96-0.mol |  |
| | N-Boc-1,3-propanediamine Chemical Properties |
| Melting point | 22 °C (lit.) | | Boiling point | 203 °C (lit.) | | density | 0.998 g/mL at 20 °C (lit.) | | refractive index | n20/D 1.454(lit.) | | Fp | >230 °F | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | Miscible with methanol. | | form | Liquid | | pka | 12.73±0.46(Predicted) | | Specific Gravity | 0.998 | | color | Colorless | | Sensitive | Air Sensitive | | BRN | 3588328 | | InChI | 1S/C8H18N2O2/c1-8(2,3)12-7(11)10-6-4-5-9/h4-6,9H2,1-3H3,(H,10,11) | | InChIKey | POHWAQLZBIMPRN-UHFFFAOYSA-N | | SMILES | NCCCNC(OC(C)(C)C)=O | | CAS DataBase Reference | 75178-96-0(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 22-34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3259 8/PG 3 | | WGK Germany | 3 | | F | 10-34 | | Hazard Note | Irritant | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29212900 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Acute Tox. 4 Oral
Skin Corr. 1B |
| | N-Boc-1,3-propanediamine Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liquid | | Uses | N-Boc-1,3-diaminopropane is used in the preparation of spermidine analogues as well as in the preparation of pharmacologically active compounds. It is also used in suzuki reaction. Further, it is used in the preparation of [3-(3-cyano-propylamino)-propyl]-carbamic acid tert-butyl ester. | | reaction suitability | reagent type: cross-linking reagent
reagent type: spacer | | Synthesis | GENERAL PROCEDURE: To a suspension of 1,3-propanediamine (20.0 g, 172 mmol) in 50 mL of dichloromethane (DCM) cooled to 0°C, a solution of di-tert-butyl dicarbonate (Boc2O, 3.75 g, 17.2 mmol) in 24 mL of DCM was slowly added. After addition, the ice bath was removed and the reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the precipitate was removed by filtration and the filtrate was washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) (3 x 50 mL), water (2 x 50 mL) and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give an oily product N-tert-butoxycarbonyl-1,3-propanediamine 3.1 g in 84% yield. | | References | [1] Journal of Organic Chemistry, 1997, vol. 62, # 2, p. 411 - 416
[2] Liebigs Annales, 1996, # 6, p. 935 - 939
[3] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 4, p. 1009 - 1018
[4] Organic and Biomolecular Chemistry, 2015, vol. 14, # 2, p. 455 - 459
[5] New Journal of Chemistry, 2018, vol. 42, # 12, p. 10142 - 10147 |
| | N-Boc-1,3-propanediamine Preparation Products And Raw materials |
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