- Tolvaptan Intermediate
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- $1.00 / 1g
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2019-08-05
- CAS:137973-76-3
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 5 tons
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| | 5-Dehydro Tolvaptan Basic information |
| Product Name: | 5-Dehydro Tolvaptan | | Synonyms: | N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide;7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine;N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbe;5-Dehydro Tolvaptan;N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-Methylphenyl)-2-MethylbenzaMide;Dehydrotolvaptan;N-[4-[7-Chloro-2,3,4,5-Tetrahydro-5-oxo-1H-1-Benzazepine-1-yl)carbonyl]-3-MethylPhenyl]-2-MethylBenzamide;N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide | | CAS: | 137973-76-3 | | MF: | C26H23ClN2O3 | | MW: | 446.93 | | EINECS: | 1312995-182-4 | | Product Categories: | Tolvaptan intermediate | | Mol File: | 137973-76-3.mol |  |
| | 5-Dehydro Tolvaptan Chemical Properties |
| Melting point | >118°C (dec.) | | Boiling point | 593.2±50.0 °C(Predicted) | | density | 1.307 | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 12.97±0.70(Predicted) | | color | White to Off-White | | InChIKey | VENGMROMZOKURN-UHFFFAOYSA-N | | SMILES | C(NC1=CC=C(C(N2C3=CC=C(Cl)C=C3C(=O)CCC2)=O)C(C)=C1)(=O)C1=CC=CC=C1C |
| | 5-Dehydro Tolvaptan Usage And Synthesis |
| Uses | 5-Dehydro Tolvaptan is an impurity of Tolvaptan (T536650), a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH g | | Preparation | To a 3 L reactor was added 1- (4-amino-2-methylbenzoyl) -7-chloro-5-oxo-2,3,4,5-tetrahydro- 1 H- 1 -benzazepine (70. 0 g, 212.90 mmol), dichloromethane (560 ml) and distilled water (140 ml), and the mixture was stirred for 1 hour. Magnesium hydroxide (14.90 g, 14.90 mmol) was added to the reaction mixture at 10 ° C. or lower, and the mixture was stirred for 30 minutes. 2-Methylbenzoyl chloride (30.42 ml) was gradually added to the reaction mixture, stirring for 3 hours. The reaction mixture was filtered to remove magnesium hydroxide, and the pH of the reaction mixture was adjusted to pH 8 to 9 using an aqueous sodium hydroxide solution, and then the organic layer was separated. The obtained organic layer was dried with sodium sulfate (Na 2 SO 4), filtered, and concentrated under reduced pressure to give 5-Dehydro Tolvaptan (yield: 96 percent). |
| | 5-Dehydro Tolvaptan Preparation Products And Raw materials |
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