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| | 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) Basic information |
| Product Name: | 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) | | Synonyms: | 3,3'-dithiopropionic acid bis(N-hydroxysuccinimide ester);Di(N-succinimidyl) 3,3μ-dithiodipropionate, Dithiobis(succinimidyl propionate), DTSP, Lomants reagent;3,3'-DITHIODIPROPIONIC ACID BIS(N-SUCCINIMIDYL ESTER);3,3'-DITHIO-BIS(PROPIONIC ACID N-HYDROXYSUCCINIMIDE ESTER);3,3'-DITHIOBIS(SUCCINIMIDYL PROPIONATE);3,3'-DITHIOPROPIONIC ACID DI(N-SUCCINIMIDYL ESTER);3,3'-DITHIODIPROPIONIC ACID DI-(N-HYDROXY-SUCCINIMIDE ESTER);3,3'-DITHIODIPROPIONIC ACID DI(N-SUCCINIMIDYL ESTER) | | CAS: | 57757-57-0 | | MF: | C14H16N2O8S2 | | MW: | 404.42 | | EINECS: | 260-931-5 | | Product Categories: | N-Substituted Maleimides, Succinimides & Phthalimides;Heterocycles;Sulfur & Selenium Compounds;Homobifunctional Crosslinker;homoXlink;N-Substituted Succinimides;ADC LINKER | | Mol File: | 57757-57-0.mol |  |
| | 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) Chemical Properties |
| Melting point | 128-133 °C | | Boiling point | 560.1±60.0 °C(Predicted) | | density | 1.57±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | chloroform: 50 mg/mL | | form | powder | | color | Off-White | | BRN | 1518074 | | CAS DataBase Reference | 57757-57-0(CAS DataBase Reference) |
| | 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) Usage And Synthesis |
| Description | DSP Crosslinker is a cleavable crosslinker. It contains two terminal NHS ester moieties which can react with primary amines. The disulfide bonds can be cleaved via a reduction reaction using Dithiothreitol (DTT) reagent. | | Chemical Properties | Off-White Solid | | Uses | 3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) has been used as a protein cross-linker. | | Uses | 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used in the crosslinking of intracellular proteins prior to cell lysis. | | Uses | 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used as amine reactive homobifunctional cross-linking reagent, cleavable under mild conditions with hydroxylamine (pH 8.5, 3-6 h, 37oC) | | General Description | 3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) is a homobifunctional cross-linking reagent containing a cleavable disulfide linkage. It is typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). |
| | 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) Preparation Products And Raw materials |
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