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Ethyl acetate

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Company Name: Shanghai Bojing Chemical Co.,Ltd.
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Products Intro: Product Name:Ethyl acetate
CAS:141-78-6
Purity:99% Package:1kg;25kg;200kg Plastic drum Remarks:Colorless liquid
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
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Products Intro: Product Name:Ethyl acetate
CAS:141-78-6
Purity:99% Package:Packaging(Various Packaging) Remarks:email: sales@crovellbio.com whatsapp/wechat: +8615203118427 skype: sales@crovellbio.com
Company Name: Henan DaKen Chemical CO.,LTD.
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Products Intro: Product Name:Ethyl acetate
CAS:141-78-6
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: CAS:141-78-6
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shanghai Time Chemicals CO., Ltd.
Tel: +86-021-57951555
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Products Intro: Product Name:Ethyl acetate
CAS:141-78-6

Lastest Price from Ethyl acetate manufacturers

  • ethyl acetate
  • US $40.00 / KG
  • 2018-12-29
  • CAS:141-78-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20 MT
  • ethyl acetate
  • US $10.00 / KG
  • 2018-10-22
  • CAS:141-78-6
  • Min. Order: 1000KG
  • Purity: 99%
  • Supply Ability: 1000 ton
Ethyl acetate Basic information
Introduction Solubility in water Purification and water removal methods Uses Production Category Toxicity grading Acute oral toxicity Irritation data Hazardous characteristics of explosive Flammability and hazard characteristics Storage characteristics Extinguishing agent Professional standards
Product Name:Ethyl acetate
Synonyms:ALCOHOL, REAGENT, DENATURED;ALCOHOL;ALCOHOL, DENATURED;ALCOHOL C2;ABSOLUTE ALCOHOL;ACETIC ESTER;ACETIC ETHER;ACETIC ACID ETHYL ESTER
CAS:141-78-6
MF:C4H8O2
MW:88.11
EINECS:205-500-4
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Mol File:141-78-6.mol
Ethyl acetate Structure
Ethyl acetate Chemical Properties
Melting point −84 °C(lit.)
Boiling point 76.5-77.5 °C(lit.)
density 0.902 g/mL at 25 °C(lit.)
vapor density 3 (20 °C, vs air)
vapor pressure 73 mm Hg ( 20 °C)
refractive index n20/D 1.3720(lit.)
FEMA 2414 | ETHYL ACETATE
Fp 26 °F
storage temp. 2-8°C
solubility Miscible with ethanol, acetone, diethyl ether and benzene.
pka16-18(at 25℃)
form Liquid
color APHA: ≤10
OdorPleasant fruity odor detectable at 7 to 50 ppm (mean = 18 ppm)
Relative polarity0.228
explosive limit2.2-11.5%, 38°F
Water Solubility 80 g/L (20 ºC)
λmaxλ: 256 nm Amax: ≤1.00
λ: 275 nm Amax: ≤0.05
λ: 300 nm Amax: ≤0.03
λ: 325-400 nm Amax: ≤0.005
Merck 14,3757
BRN 506104
Stability:Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
InChIKeyXEKOWRVHYACXOJ-UHFFFAOYSA-N
CAS DataBase Reference141-78-6(CAS DataBase Reference)
NIST Chemistry ReferenceEthyl acetate(141-78-6)
EPA Substance Registry SystemAcetic acid ethyl ester(141-78-6)
Safety Information
Hazard Codes F,Xi,Xn,T
Risk Statements 11-36-66-67-20/21/22-10-39/23/24/25-23/24/25-68/20/21/22
Safety Statements 16-26-33-36/37-45-7-25
RIDADR UN 1173 3/PG 2
WGK Germany 1
RTECS AH5425000
1
Autoignition Temperature427 °C
TSCA Yes
HS Code 2915 31 00
HazardClass 3
PackingGroup II
Hazardous Substances Data141-78-6(Hazardous Substances Data)
ToxicityLD50 orally in rats: 11.3 ml/kg (Smyth)
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Ethyl acetate Usage And Synthesis
IntroductionEthyl Acetate is an organic ester compound with a molecular formula of C4H8O2 (commonly abbreviated as EtOAc or EA), appears as a colorless liquid. It is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters), which make it a common solvent for cleaning, paint removal and coatings.
Ethyl acetate is found in alcoholic beverages, cereal crops, radishes, fruit juices, beer, wine, spirits etc. It has a fruity characteristic odor that is commonly recognized in glues, nail polish remover, decaffeinating tea and coffee, and cigarettes. Due to its agreeable aroma and low cost, this chemical is commonly used and manufactured in large scale in the world, as over 1 million tons annually.
Solubility in water8.3 g/100 mL (20 °C)
Purification and water removal methodsEthyl acetate generally has a content of 95% to 98% containing a small amount of water, ethanol and acetic acid. It can be further purified as following: add 100mL of acetic anhydride into 1000mL of ethyl acetate; add 10 drops of concentrated sulfuric acid, heat and reflux for 4h to remove impurities such as ethanol and water, and then further subject to distillation. Distillate is oscillated by 20~30g of anhydrous potassium carbonate and further subject to re-distillation. The product has a boiling point of 77 °C and purity being over 99%.
Uses
Industry Applications Role/Benefit
Flavor and essence Food flavor Used largely to prepare bananas, pears, peaches, pineapple and grape scent food flavors, etc
Alcoholic essence Used slightly as fragrance volatile
Perfume essence Used slightly as fragrance volatile
Chemical manufacture Production of acetamide, acetyl acetate, methyl heptanone, etc Organic chemical raw materials
Production of organic acid Extracting agent
Laboratory Dilution and extraction Supply excellent dissolving capacity
Chromatographic analysis Standard material
Column chromatography and extractions Main component of mobile phase
Reaction solvent Be prone to hydrolysis and transesterification
Chemical analysis Thermometer calibration for sugar separation  Standard material
Determination of bismuth, boron, gold, molybdenum, platinum and thallium Solvent
Entomology Insect collecting and study Used as effective asphyxiant to kill the collected insect quickly without destroying it
Textile industry Cleaning agent Supply excellent dissolving capacity
Printing Flexographic and rotogravure printing Dissolve the resin, control the viscosity and modify the drying rate
Electronics industry Viscosity reducer Reduce the viscosity of resins used in photoresist formulations
Paint manufacture Solvent Dissolve and dilute the paints
Health & personal care products The formulation of nail polish, nail polish removers and other manicuring products Supply excellent dissolving capacity
Pharmaceutical Medicine manufacturing Extraction agent; intermediate
Cosmetics Aroma enhancer In perfume to enhance aroma
Others Tanning extracts Used for desulfurization of tanning, cigarette materials, oil field drilling, metal flotation, descaling, etc
Production of adhesive Solvent
Extract many compounds (phosphorus, cobalt, tungsten, arsenic) from aqueous solution Extracting agent
ProductionIndustrial production of ethyl acetate is mainly classified into three processes.

The first one is a classical Fischer esterification process of ethanol with acetic acid in presence of acid catalyst. This process needs acid catalyst2 such as sulphuric acid, hydrochloride acid, ptoluene sulfonic acid etc. This mixture converts to the ester in about 65% yield at room temperature. 
CH3CH2OH + CH3COOH ↔ CH3COOC2H5 + H2O
The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water.

The second one is Tishchenko Reaction of acetaldehyde using aluminium triethoxide as a catalyst. In Germany and Japan, most ethyl acetate is produced via the Tishchenko process. 
2 CH3CHO → CH3COOC2H5
This method has been proposed by two different routes; (i) dehydrogenative process, which uses copper or palladium based catalyst and (ii) the oxidative one, which employs, PdO supported catalysts.

The third one, which has been recently commercialized, is addition of acetic acid to ethylene using clay and heteroploy acid7 as a catalyst. 
CH2= CH2 + CH3COOH → CH3COOC2H5 
The processes, however, have some disadvantages; both the conventional esterification and addition of acetic acid to ethylene need stock tanks and apparatus for several feed stocks. Moreover, they use acetic acid that causes apparatus corrosion. Although Teshchenko Reaction uses only one feed and it is a non-corrosive material, it is difficult to handle acetaldehyde because is not available outside of petrochemical industrial area.
In such circumstances, an improved process of ethyl acetate production is strongly desired.
CategoryFlammable liquid
Toxicity gradingpoisoning
Chemical PropertiesExcipient.
Chemical PropertiesEthyl acetate is a colorless liquid. Pleasant, fruity odor.
UsesPharmaceutic aid (flavor); artificial fruit essences; solvent for nitrocellulose, varnishes, lacquers, and aeroplane dopes; manufacture of smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes; cleaning textiles, etc.
Acute oral toxicityrat LD50: 5620 mg/kg; Oral-Mouse LD50: 4100 mg/kg
Irritation dataeye-people 400 PPM
Hazardous characteristics of explosiveexplosive when mixed with air
Flammability and hazard characteristicsit is flammable in case of fire, high temperature, and oxidant with burning causing irritated smoke
Storage characteristicsTreasury: ventilation, low-temperature and dry; store it separately from oxidants
Extinguishing agentdry powder, dry sand, carbon dioxide, foam, and 1211 fire extinguishing agent
Professional standardsTWA 1400 mg/m³; STEL 2000 mg/m³
Air & Water ReactionsHighly flammable. Slightly soluble in water. Ethyl acetate is slowly hydrolyzed by moisture.
Reactivity ProfileEthyl acetate is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. Ethyl acetate may ignite or explode with lithium aluminum hydride. Ethyl acetate may also ignite with potassium tert-butoxide. Ethyl acetate is incompatible with nitrates, strong alkalis and strong acids. Ethyl acetate will attack some forms of plastics, rubber and coatings. Ethyl acetate is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. . SOCl2 reacts with esters, such as Ethyl acetate, forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).
HazardToxic by inhalation and skin absorption; irritant to eyes and skin. Flammable, dangerous fire and explosion risk, flammable limits in air 2.2–9%. Questionable carcinogen.
Health HazardHeadache, irritation of respiratory passages and eyes, dizziness and nausea, weakness, loss of consciousness.
Health HazardThe acute toxicity of ethyl acetate is low. Ethyl acetate vapor causes eye, skin, and respiratory tract irritation at concentrations above 400 ppm. Exposure to high concentrations may lead to headache, nausea, blurred vision, central nervous system depression, dizziness, drowsiness, and fatigue. Ingestion of ethyl acetate may cause gastrointestinal irritation and, with larger amounts, central nervous system depression. Eye contact with the liquid can produce temporary irritation and lacrimation. Skin contact produces irritation. Ethyl acetate is regarded as a substance with good warning properties. No chronic systemic effects have been reported in humans, and ethyl acetate has not been shown to be a human carcinogen, reproductive, or developmental toxin
Fire HazardEthyl acetate is a flammable liquid (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Ethyl acetate vapor forms explosive mixtures with air at concentrations of 2 to 11.5% (by volume). Hazardous gases produced in ethyl acetate fires include carbon monoxide and carbon dioxide. Carbon dioxide or dry chemical extinguishers should be used for ethyl acetate fires
Fire HazardHIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety ProfilePotentially poisonous by ingestion. Toxicity depends upon alcohols in question, generally ethanol with methanol as a denaturant. A flammable liquid and dangerous fire hazard; can react vigorously with oxidzing materials. Moderate explosion hazard. See ETHANOL, METHYL ALCOHOL, and n-PROPYL ALCOHOL.
Potential ExposureThis material is used as a solvent for nitrocellulose and lacquer. It is also used in making dyes,flavoring and perfumery, and in smokeless powder manufacture
First aidIf this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
storageethyl acetate should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.
ShippingUN1173 Ethyl acetate, Hazard Class: 3; Labels: 3-Flammable liquid.
Purification MethodsThe most common impurities in EtOAc are water, EtOH and acetic acid. These can be removed by washing with aqueous 5% Na2CO3, then with saturated aqueous CaCl2 or NaCl, and drying with K2CO3, CaSO4 or MgSO4. More efficient drying is achieved if the solvent is further dried with P2O5, CaH2 or molecular sieves before distillation. CaO has also been used. Alternatively, ethanol can be converted to ethyl acetate by refluxing with acetic anhydride (ca 1mL per 10mL of ester), the liquid is then fractionally distilled, dried with K2CO3 and redistilled. [Beilstein 2 III 127.]
Flammability and ExplosibilityEthyl acetate is a flammable liquid (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Ethyl acetate vapor forms explosive mixtures with air at concentrations of 2 to 11.5% (by volume). Hazardous gases produced in ethyl acetate fires include carbon monoxide and carbon dioxide. Carbon dioxide or dry chemical extinguishers should be used for ethyl acetate fires.
IncompatibilitiesMay form explosive mixture with air. Heating may cause violent combustion or explosion. Incompatible with strong acids; strong alkalies; nitrates, strong oxidizers; chlorosulfonic acid; lithium aluminum hydride; oleum will hydrolyze on standing forming acetic acid and ethyl alcohol. This reaction is greatly accelerated by alkalies. Decomposes under influence of UV light, bases, and acids. Attacks aluminum and plastics.
Waste DisposalDissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≧100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Ethyl acetate Preparation Products And Raw materials
Raw materialsEtanol-->Sulfuric acid -->Acetic acid glacial-->Potassium carbonate-->1-Butanol-->Calcium oxide-->Potassium Acetate-->ketene
Preparation ProductsN-ETHYL 3-NITROBENZENESULFONAMIDE-->Methyl 4-bromo-3-nitrobenzoate-->ETHYL ISONICOTINOYLACETATE-->Sodium 1-heptanesulfonate-->D-glucose pentakis[3,4-dihydroxy-5-[(trihydroxy-3,4,5-benzoyl)oxy]benzoate] -->Ampicillin sodium-->Diphenyl N-cyanocarbonimidate-->4(1H)-Pyrimidinone, 2-methyl- (8CI,9CI)-->4-FLUOROBENZYL ISOCYANATE-->2-(2-FORMYL-PHENOXY)-PROPIONIC ACID-->N-METHOXYCARBONYLMALEIMIDE-->2-Amino-6-bromopyridine-->3-METHYL-4-PYRIDINECARBOXYLIC ACID-->N-BENZYL-6-CHLORO-N-METHYLPYRIDAZIN-3-AMINE-->polyurethane adhesive for dry laminating-->2-ISOCYANATO-4,6-DIMETHOXYPYRIMIDINE-->Methyl 3-bromo-4-methylbenzoate-->N-Acetylethylenediamine-->3-Hydroxypiperidine-->ETHYL PICOLINOYLACETATE-->N-Hexadecyltrimethylammonium chloride-->Boc-O-benzyl-L-tyrosine-->2-Acetylthiazole-->ALUMINUM DI(ISOPROPOXIDE)ACETOACETIC ESTER CHELATE-->Tea polyphenol-->2-(4-Ethoxyphenyl)-2-methylpropanol-->BOC-Glycine-->dry laminating adhesive AD-->adhesive No.1 for shrink packaging-->Triphenylsilanol-->granular adhesive PUA-->special adhesive JA-501 for laminating packaging materials-->special adhesive JA-502 for aluminum-plastics laminating tape-->Enoximone-->coating adhesive tiemao 102-->adhesive M-861 for polyolefin plastics-->self curing adhesive SL-B404-->wealant XY-2-->Water-proof adhesive-->adhesive JX-18-1
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