| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:DEPMPO-biotin
CAS:936224-52-1
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:DEPMPO-biotin
CAS:936224-52-1
Purity:98% Package:25ug (solution); 100ug (solution); 50ug (solution); 250ug (solution) Remarks:Medbio
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:DEPMPO-biotin
CAS:936224-52-1
Purity:95% Package:25μg;50μg;100μg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.com |
| Products Intro: |
Product Name:DEPMPO-biotin
CAS:936224-52-1
Purity:详情请点击官网 Package:1 mg
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:DEPMPO-biotin
CAS:936224-52-1
Package:>=95% Remarks:13251
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| | DEPMPO-biotin Basic information |
| Product Name: | DEPMPO-biotin | | Synonyms: | DEPMPO-biotin;UAQUUBGIOJZAFO-GLZOQUOBSA-N;Carbamic acid, N-[3-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]propyl]-, [(2S,3R)-2-(diethoxyphosphinyl)-3,4-dihydro-2-methyl-1-oxido-2H-pyrrol-3-yl]methyl ester | | CAS: | 936224-52-1 | | MF: | C24H42N5O8PS | | MW: | 591.66 | | EINECS: | | | Product Categories: | | | Mol File: | 936224-52-1.mol |  |
| | DEPMPO-biotin Chemical Properties |
| Melting point | 176 °C (decomp) | | Boiling point | 923.2±65.0 °C(Predicted) | | density | 1.30±0.1 g/cm3(Predicted) | | storage temp. | Store at -80°C, protect from light | | solubility | Ethanol: 10 mg/ml; Water: 1 mg/ml | | pka | 12.27±0.46(Predicted) |
| | DEPMPO-biotin Usage And Synthesis |
| Description | DEPMPO is a nitrone that is used to spin trap reactive O-, N-, S-, and C-centered radicals and allow their characterization when used in association with electron spin resonance. It is noted for the stability of adducts formed.1 DEPMPO can be used in vitro or in vivo, as it crosses lipid bilayer membranes and is a good trapping agent in biological systems.2,3 DEPMPO-biotin is a biotinylated form of DEPMPO which retains the outstanding persistency of its adducts.4 The biotin moiety offers an effective means for monitoring biodistribution in cells, tissues, and organs when used with an avidin-conjugated reporter. Importantly, DEPMPO-biotin binds free radicals, such as S-nitroso groups, on proteins, producing adducts that can be analyzed via the biotin tag. This direct labeling of S-nitrosothiols (SNO) thus serves as an effective alternative to the more cumbersome biotin-switch method for monitoring SNO formation. | | References | 1. Khan, N., Wilmont, C.M., Rosen, G.M., et al. Spin traps: In vitro toxicity and stability of radical adducts Free Radic. Biol. Med. 34(11),1473-1481(2003).
2. Anzai, K., Aikawa, T., Furukawa, Y., et al. ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes Arch. Biochem. Biophys. 415(2),251-256(2003).
3. Liu, K.J., Miyake, M., Panz, T., et al. Evaluation of DEPMPO as a spin trapping agent in biological systems Free Radic. Biol. Med. 26,714-721(1999).
4. Chalier, F., Hardy, M., Ouari, O., et al. Design of new derivatives of nitrone DEPMPO functionalized at C-4 for further specific applications in superoxide radical detection J. Org. Chem. 72,7886-7892(2007). |
| | DEPMPO-biotin Preparation Products And Raw materials |
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