ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Stem Cells & Wnt >Wnt / beta-catenin inhibitors >LGK-974

LGK-974

LGK-974 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: 21-51619050
Email: ivan@atkchemical.com
Products Intro: Product Name:LGK-974
CAS:1243244-14-5
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:LGK-974
CAS:1243244-14-5
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Email: linda@hubeijusheng.com
Products Intro: Product Name:LGK-974
CAS:1243244-14-5
Purity:0.99 Package:5KG;1KG
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: factory@coreychem.com
Products Intro: Product Name: LGK-974
CAS:1243244-14-5
Purity:97%-99% Package:1KG;6.68USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:LGK974;LGK 974;WNT974;LGK-974;NVP-LGK974
CAS:1243244-14-5
Purity:99.16% Package:1 mL * 10mM (in DMSO);10 mg;2 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

LGK-974 manufacturers

  • LGK-974
  • $6.68 / 1KG
  • 2020-01-13
  • CAS:1243244-14-5
  • Min. Order: 1KG
  • Purity: 97%-99%
  • Supply Ability: 1kg-1000kg
LGK-974 Basic information
Product Name:LGK-974
Synonyms:LGK974(NVP-LGK974);2-[5-Methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide;LGK-974;2-(2',3-diMethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetaMide;2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide;[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-;NVP-LGK974;LGK-974 2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide
CAS:1243244-14-5
MF:C23H20N6O
MW:396.44
EINECS:
Product Categories:Inhibitors
Mol File:1243244-14-5.mol
LGK-974 Structure
LGK-974 Chemical Properties
Melting point 176 - 180°C
Boiling point 650.9±55.0 °C(Predicted)
density 1.268±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
pka12.24±0.70(Predicted)
form Solid
color White to Off-White
Safety Information
MSDS Information
LGK-974 Usage And Synthesis
DescriptionPorcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4 nM). It greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. It also blocks carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal.
UsesLGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.
LGK-974 Preparation Products And Raw materials
Tag:LGK-974(1243244-14-5) Related Product Information
CHIR-99021 N,N-Dimethylbenzylamine N-Methylaniline Didecyl dimethyl ammonium chloride N,N-Dimethylbenzamide N,N'-Dimethyl-1,3-propanediamine Wnt-C59 xav-939 MG-132 Sunitinib Malate Olaparib