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CAY10683 (SantacruzaMate A)

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:CAY10683 (SantacruzaMate A)
CAS:1477949-42-0
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
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Products Intro: Product Name:CAY10683 (SantacruzaMate A)
CAS:1477949-42-0
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Products Intro: Product Name:CAY10683 (SantacruzaMate A)
CAS:1477949-42-0
Purity:0.99 Package:5KG;1KG
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:SantacruzaMate A;CAY-10683
CAS:1477949-42-0
Purity:99.16% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;2 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:SantacruzaMate A
CAS:1477949-42-0
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good

CAY10683 (SantacruzaMate A) manufacturers

CAY10683 (SantacruzaMate A) Basic information
Product Name:CAY10683 (SantacruzaMate A)
Synonyms:CAY10683 (SantacruzaMate A);ETHYL 4-OXO-4-(PHENETHYLAMINO)BUTYLCARBAMATE;N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid ethyl ester;CAY1083;Carbamic acid, N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-, ethyl ester;Santacruzamate A, >98%;CAY 10683;CAY-10683;CS-1702
CAS:1477949-42-0
MF:C15H22N2O3
MW:278.35
EINECS:
Product Categories:Inhibitors
Mol File:1477949-42-0.mol
CAY10683 (SantacruzaMate A) Structure
CAY10683 (SantacruzaMate A) Chemical Properties
Boiling point 508.1±43.0 °C(Predicted)
density 1.087±0.06 g/cm3(Predicted)
storage temp. -20°
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form solid
pka12.68±0.46(Predicted)
color Off-white
Stability:Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety Information
MSDS Information
CAY10683 (SantacruzaMate A) Usage And Synthesis
DescriptionSantacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4
UsesSantacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.
DefinitionChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.
storageStore at -20°C
References1) Pavlik?et al.?(2013),?Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod.,?76?2026 2) Zhou?et al.?(2018),?Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif.,?51(3)?e12447 3) Damaskos?et al.?(2017),?Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer;?Anticancer Res.,?37?35 4) Chen?et al.?(2019),?Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro;?Front. Cell. Neurosci.,?13?61
CAY10683 (SantacruzaMate A) Preparation Products And Raw materials
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