| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-RUNX2
Purity:Prestige Antibodies P Package:100μL Remarks:HPA022040
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| | ANTI-CORE-BINDING FACTOR ALPHA1 Basic information |
| Product Name: | ANTI-CORE-BINDING FACTOR ALPHA1 | | Synonyms: | ANTI-RUNX2;ANTI-RUNT-RELATED TRANSCRIPTION FACTOR 2;ANTI-CORE-BINDING FACTOR ALPHA1;Anti-Core-binding Factor α1, Anti-RUNT-related Transcription Factor 2;Anti-RUNX2 antibody produced in rabbit;Anti-RUNX2 (AB1) antibody produced in rabbit;Anti-RUNX2 (AB2) antibody produced in rabbit;Anti-Core-binding Factor α1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-CORE-BINDING FACTOR ALPHA1 Structure]() |
| | ANTI-CORE-BINDING FACTOR ALPHA1 Chemical Properties |
| storage temp. | −20°C | | form | ammonium sulfate suspension |
| | ANTI-CORE-BINDING FACTOR ALPHA1 Usage And Synthesis |
| Uses | All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit . | | General Description | Runt-related transcription factor 2/acute myeloid leukemia 3 protein (RUNX2, AML-3) belongs to Runt DNA-binding domain transcription factor family. RUNX2 gene is mapped to human chromosome 6p21.1 RUNX2 possesses the Runt domain, nuclear localization signal (NLS), the nuclear matrix targeting signal (NMTS) and a C-terminal VWRPY sequence. It also has two additional domains, one being the N-terminal glutamine-alanine (QA) repeats and the other a C-terminal proline/serine/threonine (PST) rich tract. RUNX2 exists in two isoforms. The isoform 1 is expressed in osteoblasts and the isoform 2 is distributed in mesenchymal condensations and mature chondrocytes. | | Biochem/physiol Actions | Runt-related transcription factor 2/ acute myeloid leukemia 3 protein (RUNX2, AML-3) mediates osteoblast differentiation and skeletal morphogenesis. It promotes mesenchymal cell differentiation in osteoblasts and its maturation. Elevated levels of RUNX2 is observed in bone?metastatic cancers. The post-translational modifications like phosphorylation, methylation, glycosylation and ubiquitination in the RUNX2 modulates osteogenesis. Mutations in the RUNX2 gene leading to loss of function is implicated in cleidocranial dysplasia (CCD). The levels of RUNX2 is elevated in osteosarcoma. |
| | ANTI-CORE-BINDING FACTOR ALPHA1 Preparation Products And Raw materials |
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