|
| 2-CHLORO-2,2-DIFLUOROACETOPHENONE Basic information |
Product Name: | 2-CHLORO-2,2-DIFLUOROACETOPHENONE | Synonyms: | CHLORODIFLUOROACETOPHENONE;alpha,alpha-Difluorophenacyl chloride;2-CHLORO-2,2-DIFLUOROACETOPHENONE;A-CHLORO-A,A-DIFLUOROACETOPHENONE;ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE;ChlorodifluoroMethyl phenyl ketone;2-Chloro-2,2-d;2-chloro-2,2-difluoro-1-phenylethanone | CAS: | 384-67-8 | MF: | C8H5ClF2O | MW: | 190.57 | EINECS: | 621-031-1 | Product Categories: | Fluorine series | Mol File: | 384-67-8.mol | |
| 2-CHLORO-2,2-DIFLUOROACETOPHENONE Chemical Properties |
Melting point | 102-103 °C | Boiling point | 94-96 °C35 mm Hg(lit.) | density | 1.293 g/mL at 25 °C(lit.) | refractive index | n20/D 1.497(lit.) | Fp | 163 °F | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | solubility | Difficult to mix. | form | liquid | color | Clear, colourless | BRN | 2251448 | CAS DataBase Reference | 384-67-8(CAS DataBase Reference) |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26-36-37 | RIDADR | UN 3334 | WGK Germany | 3 | F | 19 | Hazard Note | Irritant | HS Code | 29147000 |
| 2-CHLORO-2,2-DIFLUOROACETOPHENONE Usage And Synthesis |
Description | Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and
N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to
produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally
diverse phenol derivatives and N-heterocyclic compounds. | Uses | 2-Chloro-2,2-difluoroacetophenone can be used:
- As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
- As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
- As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.
| General Description | 2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds. |
| 2-CHLORO-2,2-DIFLUOROACETOPHENONE Preparation Products And Raw materials |
|