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Dilthiazem hydrochloride

Dilthiazem hydrochloride Suppliers list
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:Dilthiazem hydrochloride
CAS:33286-22-5
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
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Products Intro: Product Name:Dilthiazem hydrochloride
CAS:33286-22-5
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: CAS:33286-22-5
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
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Products Intro: Product Name:Dilthiazem hydrochloride
CAS:33286-22-5
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
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Products Intro: CAS:33286-22-5
Purity:98% Package:g-Kg Remarks:White crystal powder
Dilthiazem hydrochloride Basic information
Product Name:Dilthiazem hydrochloride
Synonyms:britiazim;bruzem;calcicard;cardizem;dilpral;diltiazemchloridrate;dilzem;herbesser
CAS:33286-22-5
MF:C22H27ClN2O4S
MW:450.98
EINECS:251-443-3
Product Categories:Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Calcium channel;Ion Channels;Aromatics;-;Chiral Reagents;Sulfur & Selenium Compounds;Cardiovascular APIs
Mol File:33286-22-5.mol
Dilthiazem hydrochloride Structure
Dilthiazem hydrochloride Chemical Properties
Melting point 212-214 °C
alpha D24 +98.3 ± 1.4° (c = 1.002 in methanol)
refractive index 118 ° (C=1, H2O)
Fp 2℃
storage temp. 2-8°C
solubility Freely soluble in water, in methanol and in methylene chloride, slightly soluble in anhydrous ethanol.
form Powder
color White to off-white
PHpH (10g/l, 25℃) : 4.3~5.3
Water Solubility soluble
Merck 13,3226
BRN 4228706
CAS DataBase Reference33286-22-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi,F
Risk Statements 22-40-36/37/38-36-20/21/22-11
Safety Statements 36-45-36/37-26-16
RIDADR 3249
WGK Germany 3
RTECS DL0310000
8-10
HazardClass 6.1(b)
PackingGroup III
HS Code 29349990
ToxicityLD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)
Dilthiazem hydrochloride Usage And Synthesis
Chemical PropertiesFine Needles
UsesAn antianginal, antihypertensive. Regulates Calcium release from intracellular stores in neutrophils
UsesA calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).
Usesantihypertensive, sedative, antibacterial
UsesPeripheral Vasodilator
DefinitionChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension.
Brand nameCardizem (Biovail); Cartia (Andrx); Dilacor (Watson); Diltzac (Apotex); Taztia (Andrx); Tiazac (Biovail).
General DescriptionDiltiazem hydrochloride,(+)-cis-3-(acetoxy)-5-[2(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)1,5-benzothiazepin-4(5H)one hydrochloride(Cardizem), was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.
The drug is absorbed rapidly and almost completely fromthe digestive tract. It reaches peak plasma levels within 1hour after administration in gelatin capsules. Oral formulationson the market are sustained-release preparations providingpeak plasma levels 3 to 4 hours after administration.
Biological ActivityAntihypertensive and cardioprotective agent; an inhibitor of L-type Ca 2+ channels.
Dilthiazem hydrochloride Preparation Products And Raw materials
Raw materialsEthyl propionate-->2-Aminobenzenethiol-->2-Chloroethyldimethylamine
Tag:Dilthiazem hydrochloride(33286-22-5) Related Product Information
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