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| | RESINIFERATOXIN Basic information |
| Product Name: | RESINIFERATOXIN | | Synonyms: | RESINIFERATOXIN;RESINIFERATOXIN,EUPHORBIA POISONII;RESINIFERATOXIN FROM EUPHORBIA POISONII;RESINIFERATOXIN AUS EUPHORBIA POISONII;4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(];Resiniferatoxin,Euphorbiapoisonii,Highpurity;RESINIFERATOXIN,HIGHPURITY;RESINIFERATOXIN, 99%, HIGH PURITY | | CAS: | 57444-62-9 | | MF: | C37H40O9 | | MW: | 628.71 | | EINECS: | | | Product Categories: | Agonist;Vanilloid/TRPV channel;Ion Channels;Vanilloids;Neurobiology;Pharmacologicals | | Mol File: | 57444-62-9.mol |  |
| | RESINIFERATOXIN Chemical Properties |
| Boiling point | 768.7±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO to 100mM and to 50mM in ethanol | | form | Solid | | pka | 9.85±0.20(Predicted) | | color | White to off-white | | BRN | 5371150 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Hazard Codes | T | | Risk Statements | 25-35 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2928 6.1/PG 2 | | WGK Germany | 3 | | RTECS | CY1633700 | | F | 10-23 | | HazardClass | 6.1(a) | | PackingGroup | II | | HS Code | 29329990 |
| | RESINIFERATOXIN Usage And Synthesis |
| Description | Resiniferatoxin (57444-62-9) is an ultrapotent TRPV1 activator (Ki=43 pM).1 Resiniferatoxin is 100-10,000 fold more potent than capsaicin for most responses yet displays a spectrum of activity distinct from capsaicin.2 A potent sensory neuron excitotoxin.3 Induces a long lasting analgesia in a rodent model of burn pain.4
SEVERE IRRITANT – HANDLE WITH CARE | | Chemical Properties | white to off-white solid | | Uses | Resiniferatoxin has been used as an agonist to transient receptor potential vanilloid 2 (TRPV2):
- for complex preparation for cryo-electron microscopy structural studies
- to test its effect towards immune responses to?P.?aeruginosa in sensory neurons associated with the cornea
- to study its effects in the denervation of the peripheral sensory nerves in psoriatic mice
| | Definition | ChEBI: Resiniferatoxin is a heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1). It has a role as a TRPV1 agonist, a plant metabolite, a neurotoxin and an analgesic. It is a diterpenoid, an ortho ester, a tertiary alpha-hydroxy ketone, a member of phenols, a monomethoxybenzene, an organic heteropentacyclic compound, a carboxylic ester and an enone. | | Hazard | A poison. | | Biological Activity | Ultrapotent analog of capsaicin that is an agonist at vanilloid receptors (K i = 43 pM). Like capsaicin, it acts as a selective modulator of primary afferent neurons. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ . | | Biochem/physiol Actions | Resiniferatoxin (RTX) is an analog of capsaicin. It effectively ablates corneal sensory neurons by activating transient receptor potential vanilloid 1 (TRPV1) channels. RTX facilitates corneal bacterial clearance. It also elicits protective functionality towards cardiac function in a rat model with congestive heart failure (CHF). | | References | 1) Szolcsanyi et al. (1990), Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons; J. Pharmacol. Exp. Ther., 255 923
2) Szallasi and Blumberg (1998), Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor; Life Sci. 47 1399
3) Winter et al. (1990) Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin; Brain Res. 520 131
4) Salas et al. (2017) Local Resiniferatoxin Induces Long-Lasting Analgesia in a Rat Model of Full Thickness Thermal Injury; Pain Med. 18 2453 |
| | RESINIFERATOXIN Preparation Products And Raw materials |
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