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| | Mal-amido-PEG2-TFP ester Basic information |
| Product Name: | Mal-amido-PEG2-TFP ester | | Synonyms: | Mal-amido-PEG2-TFP ester;Mal-NH-PEG2-TFP;Propanoic acid, 3-[2-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]-, 2,3,5,6-tetrafluorophenyl ester;MAL-dPEG??-TFP ester;MAL-dPEG2-TFP ester;2,3,5,6-Tetrafluorophenyl 3-(2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethoxy)propanoate | | CAS: | 1431291-44-9 | | MF: | C20H20F4N2O7 | | MW: | 476.38 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1431291-44-9.mol |  |
| | Mal-amido-PEG2-TFP ester Chemical Properties |
| storage temp. | Storage temp. -20°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Solid | | Appearance | White to off-white Solid |
| | Mal-amido-PEG2-TFP ester Usage And Synthesis |
| Description | Mal-amido-PEG2-TFP ester is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains. | | Uses | Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
| | Mal-amido-PEG2-TFP ester Preparation Products And Raw materials |
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