|
|
| | FIT-039 Basic information |
| Product Name: | FIT-039 | | Synonyms: | FIT-039;FIT-039
(FIT039);4-Pyridinecarbothioamide, N-[5-fluoro-2-(1-piperidinyl)phenyl]-;N-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridine-4-carbothioamide;N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide;Cytomegalovirus,HSV-1,Herpes simplex virus,transcription,Inhibitor,DNA,CDK,Cyclin dependent kinase,CDK9,CMV,FIT 039,mRNA,FIT039,viruses,antiviral,inhibit,orally,FIT-039,polymerase-II,HSV-2,DNA/RNA Synthesis,HSV | | CAS: | 1113044-49-7 | | MF: | C17H18FN3S | | MW: | 315.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1113044-49-7.mol |  |
| | FIT-039 Chemical Properties |
| solubility | DMSO:55.0(Max Conc. mg/mL);174.38(Max Conc. mM) | | form | A solid | | color | Light yellow to yellow |
| | FIT-039 Usage And Synthesis |
| Description | FIT-039 is a novel cyclin-dependent kinase 9 (CDK9) inhibitor, suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription. | | target | FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. |
| | FIT-039 Preparation Products And Raw materials |
|