NDI-010976

NDI-010976 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:ND630
CAS:1434635-54-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Products Intro: Product Name:NDI-010976
CAS:1434635-54-7
Purity:99% Package:1KG;7USD
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:ND-630
CAS:1434635-54-7
Package:10mg Remarks:BOC Sciences also provides custom synthesis services for ND-630.
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:NDI-010976
CAS:1434635-54-7
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:Firsocostat
CAS:1434635-54-7
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good

NDI-010976 manufacturers

  • NDI-010976
  • NDI-010976 pictures
  • $0.00 / 1KG
  • 2022-01-14
  • CAS:1434635-54-7
  • Min. Order: 1KG
  • Purity: 97.4%
  • Supply Ability: 100 tons
  • NDI-010976
  • NDI-010976 pictures
  • $7.00 / 1KG
  • 2019-07-06
  • CAS:1434635-54-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100kG
NDI-010976 Basic information
Product Name:NDI-010976
Synonyms:NDI-010976;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanoicacid;ND-630;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid;EOS-61252;GS0976;CPDB5078;(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-
CAS:1434635-54-7
MF:C28H31N3O8S
MW:569.63
EINECS:
Product Categories:API
Mol File:1434635-54-7.mol
NDI-010976 Structure
NDI-010976 Chemical Properties
Boiling point 779.0±70.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:75.0(Max Conc. mg/mL);131.66(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);17.56(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);5.27(Max Conc. mM)
form A crystalline solid
pka3.66±0.10(Predicted)
color White to light yellow
Safety Information
MSDS Information
NDI-010976 Usage And Synthesis
DescriptionND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). It is selective for ACC over 101 enzymes, receptors, growth factors, transporters, and ion channels up to a concentration of 10 μM. ND-630 prevents dimerization of ACC by interacting within the phosphopeptide-acceptor and dimerization site. It reduces fatty acid synthesis (EC50s = 66 and 9 nM in 10% FBS and serum-free media, respectively) and increases fatty acid oxidation in HepG2 cells. ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.
UsesFirsocostat or ND-630 (CAS# 1434635-54-7) is an inhibitor of acetyl-coA carboxylase and may favorably affect the morbidity and mortality associated with obesity, diabetes, and fatty liver disease from reduced hepatic steatosis, improved insulin sensitivity, and modulation of dyslipidemia.
NDI-010976 Preparation Products And Raw materials
Tag:NDI-010976(1434635-54-7) Related Product Information
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