1-甲苯磺酰-1H-吲哚-2-甲酸乙酯
| 中文名称 | 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯 |
|---|---|
| 中文同义词 | 化合物NOD-IN-1;1-甲苯磺酰-1H-吲哚-2-甲酸乙酯 |
| 英文名称 | 1H-Indole-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, ethyl ester |
| 英文同义词 | 1H-Indole-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, ethyl ester;NOD-IN-1;NOD inhibitor 1;NOD-IN-1; COMPOUND 4; MDK19922; MDK 19922; MDK-19922.;MDK19922;1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester;NODIN1,inhibit,NOD IN 1,Inhibitor,NOD-like Receptor (NLR);ethyl 1-(4-methylphenyl)sulfonylindole-2-carboxylate |
| CAS号 | 132819-92-2 |
| 分子式 | C18H17NO4S |
| 分子量 | 343.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 132819-92-2.mol |
| 结构式 |  |
1-甲苯磺酰-1H-吲哚-2-甲酸乙酯 性质
| 熔点 | 98-99 °C |
|---|---|
| 沸点 | 523.3±52.0 °C(Predicted) |
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL； DMSO:PBS (pH 7.2) (1:2)：0.33 mg/mL |
| 形态 | 结晶固体 |
NOD-IN-1 (MDK19922, Compound 4) 是一种有效的 nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) 和 NOD2 的混合抑制剂，对应的IC50值分别为5.74 μM和6.45 μM。
IC50: 5.74 μM (NOD1), 6.45 μM (NOD2)
NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC 50 (NOD1)=5.74 μM; IC 50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100691 | 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯 NOD-IN-1 | 132819-92-2 | 1mg | 800元 |
| 2024/04/30 | HY-100691 | 1-甲苯磺酰-1H-吲哚-2-甲酸乙酯 NOD-IN-1 | 132819-92-2 | 10mM * 1mLin DMSO | 1130元 |