Vadadustat manufacturers
- Vadadustat
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- $0.00 / 1g
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2021-10-08
- CAS:1000025-07-9
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1000kgs
- Vadadustat
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- $9.80 / 1.79999995231628KG
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2020-01-09
- CAS:1000025-07-9
- Min. Order: 1g
- Purity: ≥99%
- Supply Ability: 100kg
Related articles - Synthesis of Vadadustat
- Vadadustat is used as raw material of boronic acid and is prepared by coupling, substitution and hydrolysis reactions.
- Dec 22，2023
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| | Vadadustat Basic information |
| Product Name: | Vadadustat | | Synonyms: | Vadadustat;AKB-6548; AKB 6548; AKB6548; PG-1016548; PG 1016548; PG1016548; B-506; B506; VADADUSTAT;PG-1016548;AKB-6548;Vadadustat(AKB-6548/PG-1016548);Vadadustat (AKB-6548);AKB-6548;PG 1016548;PG1016548 | | CAS: | 1000025-07-9 | | MF: | C14H11ClN2O4 | | MW: | 306.7 | | EINECS: | | | Product Categories: | API | | Mol File: | 1000025-07-9.mol |  |
| | Vadadustat Chemical Properties |
| Melting point | 172-174°C | | Boiling point | 674.6±55.0 °C(Predicted) | | density | 1.461±0.06 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 4.09±0.40(Predicted) | | color | Pale Beige to Light Beige | | Stability: | Hygroscopic |
| | Vadadustat Usage And Synthesis |
| Description | Vadadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 (IC50s = 1.1 and 0.39 micromolar, respectively). It stabilizes HIF-1α in mouse hepatocyte nuclear extracts. Vadadustat (50 and 100 mg/kg) increases erythropoietin levels in mouse serum. | | Uses | Vadadustat is a novel HIF (Hypoxia-inducible factor) stabilizer. It provides an effective anemia treatment in nondialysis-dependent chronic kidney disease. |
| | Vadadustat Preparation Products And Raw materials |
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