| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:Leucettine L41
CAS:1112978-84-3
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| | Leucettine L41 Basic information |
| Product Name: | Leucettine L41 | | Synonyms: | Leucettine L41;4H-Imidazol-4-one, 5-(1,3-benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-, (5Z)-;Leucettine L41,Leucettine L-41 | | CAS: | 1112978-84-3 | | MF: | C17H13N3O3 | | MW: | 307.3 | | EINECS: | | | Product Categories: | | | Mol File: | 1112978-84-3.mol |  |
| | Leucettine L41 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: soluble; Ethanol: soluble | | form | A solid |
| | Leucettine L41 Usage And Synthesis |
| Description | Leucettine L41 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 μM, respectively).1 It also inhibits GSK3α/β and Pim1 with IC50 values of 0.41 and 4.1 μM, respectively. It inhibits phosphorylation of the serine/arginine (SR) protein 9G8 by DYRK2, DYRK3, CLK1, CLK2, and CLK4 and inhibits TNF-α-induced SRp75 and SRp55 phosphorylation in human microvascular endothelial cells when used at concentrations ranging from 0.1 to 10 μM. Leucettine L41 modulates alternative pre-RNA splicing of a synthetic CLK1 minigene in a reporter model. It prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by amyloid-β 25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity.2 Leucettine L41 (0.4, 1.2, and 4 μg, i.c.v.) also prevents memory deficits induced by amyloid-β 25-35 in the same model. | | References | 1. Debdab, M., Carreaux, F., Renault, S., et al. Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: Modulation of alternative pre-RNA splicing J. Med. Chem. 54(12),4172-4186(2011).
2. Naert, G., Ferré, V., Meunier, J., et al. Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice Eur. Neuropsychopharmacol. 25(11),2170-2182(2015). |
| | Leucettine L41 Preparation Products And Raw materials |
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