|
|
| | 4-Fluorophenylacetic acid Basic information |
| | 4-Fluorophenylacetic acid Chemical Properties |
| | 4-Fluorophenylacetic acid Usage And Synthesis |
| Chemical Properties | white shiny crystalline powder or flakes | | Uses | 4-Fluorophenylacetic acid is used as an intermediate in the production of fluorinated anesthetics. | | Synthesis Reference(s) | Journal of the American Chemical Society, 78, p. 6037, 1956 DOI: 10.1021/ja01604a023 | | Purification Methods | Crystallise it from heptane, but it is best purified by distillation at high vacuum. [Bergmann et al. J Am Chem Soc 78 6037 1956, Beilstein 9 III 2261, 9 IV 1672.] |
| | 4-Fluorophenylacetic acid Preparation Products And Raw materials |
| Raw materials | 2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE-->Benzaldehyde, 4-fluoro-, hydrazone (9CI)-->2,3,4,6-Tetra-O-pivaloyl-D-glucopyranosyl amine-->METHYL 4-FLUOROPHENYLACETATE-->4-Fluorobenzylboronic acid pinacol ester-->4-FLUOROPHENYLACETIC ACID ETHYL ESTER-->4-Fluorophenylacetylene-->4-Fluorobenzyl bromide-->4-Fluorostyrene-->4-Fluorobenzyl chloride | | Preparation Products | 4-Fluorophenylacetyl chloride-->1,2-BIS-(4-FLUOROPHENYL)ETHANONE-->4-FLUOROBENZYL ISOCYANATE-->N-(2,2-Dichloro-1-hydroxyethyl)-4-fluorobenzeneacetamide-->(4-Fluorophenyl)acetic-2,2-d2 Acid |
|