N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl)

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Products Intro:	Product Name:N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) CAS:2112737-71-8 Purity:98.00% Package:5mg;61USD\|2mg;39USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Hangzhou MolCore BioPharmatech Co.,Ltd.
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Products Intro:	Product Name:N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) CAS:2112737-71-8 Purity:95%+ Remarks:MC739242

Company Name:	Jilin Chinese Academy of Sciences-yanshen Technology
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Products Intro:	Product Name:N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) CAS:2112737-71-8 Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing

Company Name:	Xian confluore Biological Technology Co., Ltd.
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Company Name:	Aladdin Scientific
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Products Intro:	Product Name:N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) CAS:2112737-71-8 Purity:98% Package:$1051.9/100mg;$2041.9/250mg;$3301.9/500mg;Bulk package Remarks:98%

N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) manufacturers

N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) Basic information

Product Name:	N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl)
Synonyms:	N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl);Ethanamine, 2-[2-[2-(aminooxy)ethoxy]ethoxy]-N,N-bis[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]ethyl]-
CAS:	2112737-71-8
MF:	C24H44N2O9
MW:	504.61
EINECS:
Product Categories:
Mol File:	2112737-71-8.mol

N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) Chemical Properties

form	Liquid
color	Light yellow to yellow

Safety Information

MSDS Information

N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) Usage And Synthesis

Description	N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) consists of two terminal propargyl groups and an aminooxy group. The propargyl groups reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The aminooxy group is reactive towards aldehydes to form oxime bonds. If a reductant is used, it will form a hydroxylamine linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
Uses	N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50	PEGs
References	[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) Preparation Products And Raw materials

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