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10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE

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10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
CAS:122955-42-4
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
CAS:122955-42-4
Purity:38799% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:XE-991
CAS:122955-42-4
Purity:98% Package:$101.9/5mg;$156.9/10mg;$352.9/25mg;$665.9/50mg;$1197.9/100mg;Bulk package Remarks:98%
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:XE 991 dihydrochloride;10,10-bis(4-PyridinylMethyl)-9(10H)-anthracenonedihydrochloride
CAS:122955-42-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Ascent Scientific  
Tel: 4401179829988
Email: customerservice@ascentscientific.co.uk
Products Intro: Product Name:XE-991 dihydrochloride
CAS:122955-42-4
Purity:>99% Package:10mg;50mg Remarks:Potent, selective KCNQ channel blocker; blocks M current
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Basic information
Product Name:10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
Synonyms:10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE;XE9912HCl;XE 991;XE 991 DIHYDROCHLORIDE;10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride;9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one
CAS:122955-42-4
MF:C26H20N2O
MW:376.45
EINECS:
Product Categories:Ion Channels;Potassium channel
Mol File:122955-42-4.mol
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Structure
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Chemical Properties
Melting point 231-232 °C
Boiling point 585.0±38.0 °C(Predicted)
density 1.238±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
form solid
pka6.08±0.10(Predicted)
color white to beige
Water Solubility Soluble in water (100mM)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS CB1530000
MSDS Information
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Usage And Synthesis
UsesXE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).
Biological ActivityPotent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2+3/M-currents (IC 50 = 0.6-0.98 μ M) and KCNQ1 homomeric channels (IC 50 = 0.75 μ M) but is less potent against KCNQ1/minK channels (IC 50 = 11.1 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo .
Biochem/physiol ActionsXE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).
storageRoom temperature (desiccate)
10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Preparation Products And Raw materials
Tag:10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE(122955-42-4) Related Product Information
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