| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:PAPA NONOate
CAS:146672-58-4
Purity:>98% Package:5x5mg, 25mg
|
| Company Name: |
Shanghai Macklin Biochemical Co.,Ltd.
|
| Tel: |
15221275939 |
| Email: |
shenlinxing@macklin.cn |
| Products Intro: |
Product Name:PAPA NONOate
CAS:146672-58-4
Purity:98% Package:5mg；25mg；100mg
|
PAPA NONOATE manufacturers
- PAPA NONOate
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- $49.00 / 2mg
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2025-09-15
- CAS:146672-58-4
- Min. Order:
- Purity: 98.00%
- Supply Ability: 10g
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| | PAPA NONOATE Basic information |
| Product Name: | PAPA NONOATE | | Synonyms: | 3-(2-HYDROXY-2-NITROSO-1-PROPYLHYDRAZINO)-1-PROPANAMINE NONOATE;1-HYDROXY-2-OXO-3-(3-AMINOPROPYL)-3-PROPYL-1-TRIAZENE;(Z)-1-[N-(3-AMMONIOPROPYL)-N-(N-PROPYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE;(Z)-1-[N-(3-AMINOPROPYL)-N-)B-PROPYL)AMINO]DIAZIN-1-IUM-1,2-DIOLATE;PROPYLAMINE PROPYLAMINE NONOATE;PAPA/NO;PAPA NONOATE;NOC-15 | | CAS: | 146672-58-4 | | MF: | C6H16N4O2 | | MW: | 176.22 | | EINECS: | | | Product Categories: | | | Mol File: | 146672-58-4.mol |  |
| | PAPA NONOATE Chemical Properties |
| Boiling point | 277.2±42.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in Water or Ethanol. | | form | White to off-white solid. | | pka | 5.55±0.69(Predicted) | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use. |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | PAPA NONOATE Usage And Synthesis |
| Description | PAPA NONOate (146672-58-4) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of PAPA NONOate in 0.1 M phosphate buffer at pH 7.4 is 15 minutes at 37°C, or 77 minutes at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0. | | Uses | PAPA NONOate is an NO donor which suppresses the caspase apoptotic cascade. | | Definition | ChEBI: PAPA NONOate is an alkylamine. | | in vivo | PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2]. | Animal Model: | Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2] | | Dosage: | 100 μM | | Administration: | Wounds received 100 μM PAPA NONOate in phosphate buffer | | Result: | Increased the wound healing rate in test group.
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| | References | [1] L K KEEFER. “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms.[J]. Methods in enzymology, 1996, 268: 281-293. DOI:10.1016/s0076-6879(96)68030-6 |
| | PAPA NONOATE Preparation Products And Raw materials |
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