- Flavopiridol
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- $15.00 / 1KG
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2021-07-02
- CAS:146426-40-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Flavopiridol
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- $3.00 / 1KG
-
2020-01-10
- CAS:146426-40-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 200KG
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| | Flavopiridol Basic information |
| Product Name: | Flavopiridol | | Synonyms: | FLAVOPIRIDOL;2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one;4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-;(-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one;C077990;Hmr 1275;L 868275;L-868275 | | CAS: | 146426-40-6 | | MF: | C21H20ClNO5 | | MW: | 401.84 | | EINECS: | | | Product Categories: | API intermediates;APIS | | Mol File: | 146426-40-6.mol |  |
| | Flavopiridol Chemical Properties |
| Melting point | 52.5 °C | | Boiling point | 603.6±55.0 °C(Predicted) | | density | 1.448±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic | | form | Yellow powder. | | pka | 6.16±0.40(Predicted) | | InChIKey | BIIVYFLTOXDAOV-YVEFUNNKSA-N | | SMILES | C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1 | | CAS DataBase Reference | 146426-40-6(CAS DataBase Reference) |
| | Flavopiridol Usage And Synthesis |
| Uses | Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses. | | Uses | Antineoplastic (cyclin-dependent kinase
inhibitor)[Note—The trivial name, flavopiridol, has
appeared in literature]. | | Definition | ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+). | | Anticancer Research | It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006). |
| | Flavopiridol Preparation Products And Raw materials |
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