- 4-CHLORO-2-BUTANONE
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- $10.00 / 1KG
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2025-11-27
- CAS:6322-49-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- 4-CHLORO-2-BUTANONE
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- $20.00 / 25kg
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2024-04-25
- CAS:6322-49-2
- Min. Order: 1kg
- Purity: 99.9%
- Supply Ability: 200000kg
- 4-CHLORO-2-BUTANONE
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- $6509.00 / 1KG
-
2020-06-30
- CAS:6322-49-2
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1T
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| | 4-CHLORO-2-BUTANONE Basic information |
| | 4-CHLORO-2-BUTANONE Chemical Properties |
| Boiling point | 146℃ | | density | 1.033 | | refractive index | 1.4299-1.4334 | | Fp | 45℃ | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Chloroform, Ethyl Acetate (Slightly) | | form | Oil | | color | Black | | InChI | InChI=1S/C4H7ClO/c1-4(6)2-3-5/h2-3H2,1H3 | | InChIKey | MAGOYBJJLVSJIC-UHFFFAOYSA-N | | SMILES | CC(=O)CCCl | | LogP | 0.666 (est) |
| | 4-CHLORO-2-BUTANONE Usage And Synthesis |
| Chemical Properties | Liquid. Boiling point 123°C (98 kPa, decomposition), 55°C (2.13 kPa), relative density 1.068 (23/4°C), refractive index 1.4284 (23°C). | | Uses | 4-Chloro-2-butanone acts as a reagent for the preparation of pyrrolopyrazine derivatives as selective spleen tyrosine kinase inhibitors. | | Application |
4-Chloro-2-butanone is a reagent for Robinson annulation; often interchangeable with methyl vinyl ketone and the corresponding Mannich base 4-dialkylamino-2-butanone.
| | Synthesis Reference(s) | Synthetic Communications, 26, p. 3479, 1996 DOI: 10.1080/00397919608003752 | | Synthesis | General procedure for the synthesis of β-chlorobutanone from 4-hydroxy-2-butanone: 4-hydroxy-2-butanone (0.881 g, 10 mmol), dichloromethane (2 ml), and thionyl chloride (1.46 ml, 20 mmol) were added in a reaction flask and the reaction was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator and the residue was dried with a stream of nitrogen to give 2-chlorobutan-2-one (1.06 g). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 2.12 (s, 3H), 2.94 (t, 2H), 3.74 (t, 2H). | | References | [1] Angewandte Chemie - International Edition, 2012, vol. 51, # 27, p. 6713 - 6716
[2] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1936, vol. 202, p. 1687
[3] Zhurnal Obshchei Khimii, 1938, vol. 8, p. 909
[4] Chem. Zentralbl., 1939, vol. 110, # I, p. 4953
[5] Patent: WO2015/169999, 2015, A1. Location in patent: Page/Page column 63 |
| | 4-CHLORO-2-BUTANONE Preparation Products And Raw materials |
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