3,3'-Diindolylmethane

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Company Name: Hebei Yanxi Chemical Co., Ltd.
Tel: +8617531190177
Email: peter@yan-xi.com
Products Intro: Product Name:3,3'-Diindolylmethane
CAS:1968-05-4
Purity:0.99 Package:1kg Remarks:Factory direct sales
Company Name: Hebei Fengqiang Trading Co., LTD
Tel: +8613373049370
Email: kaia@hbfengqiang.com
Products Intro: Product Name:3,3'-Diindolylmethane
CAS:1968-05-4
Purity:99 Package:1bag;100USD
Company Name: Nantong Guangyuan Chemicl Co,Ltd
Tel: +86-053189075150 +86-17331189928
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Products Intro: Product Name:3,3'-Diindolylmethane
CAS:1968-05-4
Purity:99% Package:1kg;10USD
Company Name: Capot Chemical Co.,Ltd.
Tel: 571-85586718 +8613336195806
Email: sales@capotchem.com
Products Intro: Product Name:Di(1H-indol-3-yl)methane
CAS:1968-05-4
Purity:98%(Min,HPLC) Package:1G;1KG;100KG
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
Tel: +86-371-66670886
Email: info@dakenam.com
Products Intro: Product Name:3,3'-Diindolylmethane
CAS:1968-05-4
Purity:99% Package:100g ;1KG ;5KG 25KG

3,3'-Diindolylmethane manufacturers

  • 3,3'-Diindolylmethane
  • 3,3'-Diindolylmethane pictures
  • $0.00 / 1KG
  • 2024-02-22
  • CAS:1968-05-4
  • Min. Order: 1KG
  • Purity: 99% HPLC
  • Supply Ability: 1000KG
  • 3,3'-Diindolylmethane
  • 3,3'-Diindolylmethane pictures
  • $10.00 / 1kg
  • 2024-02-22
  • CAS:1968-05-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 1000kg
  • 3,3'-Diindolylmethane
  • 3,3'-Diindolylmethane pictures
  • $0.00 / 1kg
  • 2024-02-22
  • CAS:1968-05-4
  • Min. Order: 1kg
  • Purity: 3 3'-Diindolylmethane Dim Diindolylmethane
  • Supply Ability: 3000kg
3,3'-Diindolylmethane Basic information
Product Name:3,3'-Diindolylmethane
Synonyms:3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl);Plant Indole;3,3'-DIINDOLYLMETHANE, >=98% (HPLC);3,3'-METHYLENEBIS-1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE
CAS:1968-05-4
MF:C17H14N2
MW:246.31
EINECS:100-201-5
Product Categories:Inhibitors;Pharmaceutical intermediates;Gene Regulation;Gene Regulation and Expression;Alkaloid;Antitumor Agents;Aromatic Compounds;Building Blocks;C13 to C27;Cancer Research;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Enzyme Inhibitors;Heterocyclic Building Blocks;Nutrition Research;Phytochemicals by Chemical Classification;Indoles and derivatives;IndoleDerivative;Indoline & Oxindole;Indoles;Simple Indoles;1968-05-4
Mol File:1968-05-4.mol
3,3'-Diindolylmethane Structure
3,3'-Diindolylmethane Chemical Properties
Melting point 167 °C
Boiling point 230 °C(Press: 0.01 Torr)
density 1.271±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Sparingly), Methanol (Slightly)
pka16.91±0.30(Predicted)
form Off-white powder.
color White to Pale Beige
InChIInChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
InChIKeyVFTRKSBEFQDZKX-UHFFFAOYSA-N
SMILESC(C1C2=C(NC=1)C=CC=C2)C1C2=C(NC=1)C=CC=C2
LogP4.401 (est)
CAS DataBase Reference1968-05-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-26
WGK Germany 3
RTECS NM0332000
HazardClass IRRITANT
HS Code 29349990
MSDS Information
3,3'-Diindolylmethane Usage And Synthesis
Chemical PropertiesSolid
Uses3,3′-Diindolylmethane may be used as a model substrate to analyze the role of 3,3′-diindolylmethane in inducing apoptosis in human cancer cells.
UsesAn antineoplastic agent that activates Chk 2 and cytochrome p450
Usesapoptosis inducer
DefinitionChEBI: 3,3'-diindolylmethane is a member of indoles. It has a role as an antineoplastic agent and a P450 inhibitor.
General Description3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects.
Biological Activity3,3'-diindolylmethane is an anticancer agent [1].3,3'-diindolylmethane (dim) is a dimer of indole-3-carbinol generated in low ph environment. it inhibited cell growth with ic50 values of 17, 24 and 30 μm in mcf-7, t47d and saos2 cell lines, respectively. dim induced apoptosis in these cells without affecting the p53 pathway. in human nasopharyngeal carcinoma (npc) cell line (5-8f npc), treatment of dim decreased the ability of cell migration and invasion dose-dependently. in rats, transplanted with npc cells, dim administration resulted in suppressing lymph node metastasis. besides that, dim was found to induce erα target gene expression and the concomitant cell proliferation at low concentration (10μm) in the absence of e2 [1, 2 and 3].
Biochem/physiol ActionsAcid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system.
references1. ge x, yannai s, rennert g, et al. 3, 3′-diindolylmethane induces apoptosis in human cancer cells. biochemical and biophysical research communications, 1996, 228(1): 153-158. 2. wu t, chen c, li f, et al. 3, 3' diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. experimental and therapeutic medicine, 2014, 7(6): 1635-1638. 3. marques m, laflamme l, benassou i, et al. low levels of 3, 3 [prime]-diindolylmethane activate estrogen receptor alpha and induce proliferation of breast cancer cells in the absence of estradiol. bmc cancer, 2014, 14(1): 524.
3,3'-Diindolylmethane Preparation Products And Raw materials
Preparation Products5,11-dihydro-5-phenylindolo[3,2-b]carbazole
Tag:3,3'-Diindolylmethane(1968-05-4) Related Product Information
4-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-2-METHOXYPHENOL 2-[2,2-BIS-(1H-INDOL-3-YL)-ETHYL]-PHENYLAMINE 4-(2-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-4,6-DICHLOROPHENYL)MORPHOLINE 4-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-2,6-DIMETHOXYPHENOL 3,3'-((5-BROMO-2-METHOXYPHENYL)METHYLENE)BIS(2-METHYL-1H-INDOLE) 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-(1-(1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-INDOL-3-YL)VINYL)-1H-INDOLE 1'-ACETYL-1H,1'H-3,3':3',3'-TERINDOL-2'(1'H)-ONE 1-(3-[1-(1-ACETYL-1H-INDOL-3-YL)VINYL]-1H-INDOL-1-YL)-1-ETHANONE 1H-INDOL-3-OL 2-METHYL-3-[(5-METHYL-2-FURYL)(2-METHYL-1H-INDOL-3-YL)METHYL]-1H-INDOLE 3,3'-DIINDOLYLMETHANOL [4-[BIS(2-METHYLINDOL-3-YL)METHYL]]DIMETHYLANILINE 3,3'-((4-METHOXYPHENYL)METHYLENE)BIS(2-P-TOLYL-1H-INDOLE) 1-(2,4-DICHLOROBENZYL)-3-(1-[1-(2,4-DICHLOROBENZYL)-1H-INDOL-3-YL]VINYL)-1H-INDOLE 3,3'-Diindolylmethane 3,3'-((3,4-DIMETHOXYPHENYL)METHYLENE)BIS(2-P-TOLYL-1H-INDOLE) 4-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-2-ETHOXYPHENOL AURORA 23218