S-(3-二甲氨基丙基)异硫脲二盐酸盐
| 中文名称 | S-(3-二甲氨基丙基)异硫脲二盐酸盐 |
|---|---|
| 中文同义词 | 2-(3'-二甲基氨基丙基硫基)异脲二盐酸盐;DIMAPRIT 盐酸盐;S-(3-二甲氨基丙基)异硫脲二盐酸盐;3-(二甲胺基)丙基 亚胺代硫代甲酸酯 二盐酸盐;盐酸双马普利 |
| 英文名称 | DIMAPRIT DIHYDROCHLORIDE |
| 英文同义词 | carbamimidothioicacid,3-(dimethylamino)propylester,dihydrocloride;diamaprit-2hcl;dimaprithydrochloride;usafpd-40;Carbamimidothioic acid, 3-(dimethylamino)propyl ester, dihydrocloride (9ci);Pseudourea, 2-(3-(dimethylamino)propyl)-2-thio-, dihydrochloride;3-(dimethylamino)propyl carbamimidothioate 2HCl;(S)-(3-Dimethylaminopropyl)isothiourea dihydochloride |
| CAS号 | 23256-33-9 |
| 分子式 | C6H16ClN3S |
| 分子量 | 197.73 |
| EINECS号 | |
| 相关类别 | Histamine receptor |
| Mol文件 | 23256-33-9.mol |
| 结构式 |  |
S-(3-二甲氨基丙基)异硫脲二盐酸盐 性质
| 储存条件 | Desiccate at RT |
|---|---|
| 溶解度 | H2O：≥50mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble to 100 mM in water |
|
H 2 Receptor
|
nNOS 49 μM (IC 50 ) |
Dimaprit has less than 0.0001% the activity of histamine on H1-receptors.
Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC
50
of 49±14 μM.
Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.).
Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate.