S-(3-二甲氨基丙基)异硫脲二盐酸盐
| 中文名称 | S-(3-二甲氨基丙基)异硫脲二盐酸盐 |
|---|---|
| 中文同义词 | 2-(3'-二甲基氨基丙基硫基)异脲二盐酸盐;DIMAPRIT 盐酸盐;S-(3-二甲氨基丙基)异硫脲二盐酸盐;3-(二甲胺基)丙基 亚胺代硫代甲酸酯 二盐酸盐;盐酸双马普利;DIMAPRIT DIHYDROCHLORIDE,H2激动剂;【进口分装现货】盐酸双马普利23256-33-9;【进口分装现货】盐酸双马普利23256-33-9 |
| 英文名称 | Dimaprit dihydrochloride |
| 英文同义词 | carbamimidothioicacid,3-(dimethylamino)propylester,dihydrocloride;diamaprit-2hcl;dimaprithydrochloride;usafpd-40;Carbamimidothioic acid, 3-(dimethylamino)propyl ester, dihydrocloride (9ci);Pseudourea, 2-(3-(dimethylamino)propyl)-2-thio-, dihydrochloride;3-(dimethylamino)propyl carbamimidothioate 2HCl;(S)-(3-Dimethylaminopropyl)isothiourea dihydochloride |
| CAS号 | 23256-33-9 |
| 分子式 | C6H16ClN3S |
| 分子量 | 197.73 |
| EINECS号 | |
| 相关类别 | Histamine receptor |
| Mol文件 | 23256-33-9.mol |
| 结构式 |  |
S-(3-二甲氨基丙基)异硫脲二盐酸盐 性质
| 储存条件 | Desiccate at RT |
|---|---|
| 溶解度 | H2O：≥50mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble to 100 mM in water |
| InChI | 1S/C6H15N3S.2ClH/c1-9(2)4-3-5-10-6(7)8;;/h3-5H2,1-2H3,(H3,7,8);2*1H |
| InChIKey | DFWCPLGXFMSUCW-UHFFFAOYSA-N |
| SMILES | Cl.Cl.CN(C)CCCSC(N)=N |
|
H 2 Receptor
|
nNOS 49 μM (IC 50 ) |
Dimaprit has less than 0.0001% the activity of histamine on H1-receptors.
Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC
50
of 49±14 μM.
Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.).
Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-B1478 | S-(3-二甲氨基丙基)异硫脲二盐酸盐 Dimaprit dihydrochloride | 23256-33-9 | 25 mg | 600元 |
| 2026/09/15 | HY-B1478 | S-(3-二甲氨基丙基)异硫脲二盐酸盐 Dimaprit dihydrochloride | 23256-33-9 | 10 mM * 1 mLin DMSO | 660元 |