SR 11237
中文名称 | SR 11237 |
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中文同义词 | 化合物 T23383;化合物SR11237;SR 11237,泛RXR激动剂;4-(2-(5,5,8,8-四甲基-5,6,7,8-四氢萘-2-基)-1,3-二氧戊环-2-基)苯甲酸 |
英文名称 | SR 11237 |
英文同义词 | SR 11237;4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoicacid;4-(2-(5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acid;BMS 188649;BMS649;Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-;Retinoid X receptors,bone,BMS 649,transactivate,BMS649,Retinoic acid receptors,reporter,ossification,RAR/RXR,inhibit,Inhibitor,RXR/RXR,BMS-649,SR11237,homodimers,gene,SR-11237 |
CAS号 | 146670-40-8 |
分子式 | C24H28O4 |
分子量 | 380.48 |
EINECS号 | |
相关类别 | |
Mol文件 | 146670-40-8.mol |
结构式 |
SR 11237 性质
储存条件 | Store at -20°C |
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溶解度 | DMSO:>28mg/mL(加热) |
形态 | 粉末 |
颜色 | 白色至类白色 |
SR11237 (BMS-649) 是一种视黄醇 X 受体 (RXR) 选择性激动剂,没有任何 RAR 活性。SR11237可导致 RXR/RXR 同型二聚体形成并激活含有 RXR 反应元件的报告基因。
Using nuclear receptor co-transfection assays in COS-1 cells, that SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors.
SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate.
Animal Model: | Sprague-Dawley rats |
Dosage: | 25 mg/kg |
Administration: | I.p.; daily from post-natal days 5 to 15 |
Result: | Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis. |
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-107413 | SR11237 | 1 mg | 800元 | |
2024/08/19 | HY-107413 | SR 11237 SR11237 | 146670-40-8 | 5mg | 1900元 |