阿拉磷
| 中文名称 | 阿拉磷 |
|---|---|
| 中文同义词 | 阿拉磷;L-丙氨酰-L-1-氨基乙基膦酸;化合物 T25021;L-丙氨酰基-L-1-氨基乙基膦酸;L-丙氨酰基-L-1-氨基乙基膦酸;(R)-1-((S)-2-氨基丙酰胺基)乙基)磷酸;阿拉磷相关杂质;((1R)-1-((2S)-2-氨基丙酰胺基)乙基)膦酸 |
| 英文名称 | (S)-Alanyl-(R)-1-aminoethylphosphonic acid |
| 英文同义词 | L-ALANYL-L-1-AMINOETHYLPHOSPHONIC ACID;L-ALANYL-L-ALA(P)-OH;(S)-Alanyl-(R)-1-aminoethylphosphonic acid, Alafosfalin, Alaphosphin;[(1R)-1-[[(2S)-2-Aminopropanoyl]amino]ethyl]phosphonic acid;L-ALANYL-L-ALA(P)-OH, (S)-ALANYL-(R)-1-AMINOETHYLPHOSPHONIC ACID;Alafosfalin >97%;Phosphonic acid, P-[(1R)-1-[[(2S)-2-amino-1-oxopropyl]amino]ethyl]-;((R)-1-((S)-2-Aminopropanamido)ethyl)phosphonic acid |
| CAS号 | 60668-24-8 |
| 分子式 | C5H13N2O4P |
| 分子量 | 196.14 |
| EINECS号 | 262-362-8 |
| 相关类别 | |
| Mol文件 | 60668-24-8.mol |
| 结构式 |  |
阿拉磷 性质
| 熔点 | 295-296° (dec) |
|---|---|
| 比旋光度 | D20 -44.0° (c = 1 in H2O) |
| 密度 | 1.395±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 甲醇（少量溶解）、水（少量溶解） |
| 酸度系数(pKa) | 2.60±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 无色或白色 |
| 旋光度 (Optical Rotation) | [α]20/D 45±2°, c = 1% in H2O |
| Merck | 13,202 |
| BRN | 4801790 |
Alafosfalin 是一种细胞壁生物合成抑制剂。Alafosfalin 是一种磷酸二肽，具有抗菌 (antibacterial) 特性。
Antibacterial
Alafosfalin is highly active against Escherichia coli and moderately active against Serratia , Klebsiella , Enterobacter , and Citrobacter , but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus , Pseudomonas , and Acinetobacter .
After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t 1/2 ) of approximately 20 minutes.
| Animal Model: | Pairs of male SpragueDawley rats (250 to 350 g) |
| Dosage: | 20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis) |
| Administration: | Administrated by s.c. |
| Result: | Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes. |