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Meropenem Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Products Intro: Product Name:Meropenem
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Meropenem
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:96036-03-2
Purity:0.99 Package:25KG,5KG;1KG;500G
Tel: +86 21 5161 9050/ 5187 7795
Products Intro: Product Name:Meropenem
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
Company Name: Hebei Chisure Biotechnology Co., Ltd.
Tel: +8613292890173
Products Intro: Product Name:Meropenem
Purity:99% Package:1KG;10USD

Lastest Price from Meropenem manufacturers

  • Meropenem
  • US $7.00 / kg
  • 2019-07-06
  • CAS: 96036-03-2
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100KG
  • Meropenem
  • US $1.00 / kg
  • 2019-07-06
  • CAS:96036-03-2
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100KG
  • Meropenem
  • US $10.00 / KG
  • 2019-05-06
  • CAS:96036-03-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 500tons/month
Meropenem Basic information
Brand Name(s) in US Semi-synthetic carbapenem antibiotics Indications Antibacterial scope Comparison among three kinds of carbapenems antibiotics Dosage Side effects Drug Interactions Uses
Product Name:Meropenem
Synonyms:STERILE MEROPENEM;STERILE MIXTURE OF MEROPENEM AND SODIUM CARBONATE;1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, (4R,5S,6S)- (9CI);1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-, [4R-[3(3S*,5S*),4a,5b,6b(R*)]]-;SM 7338;Meropenem;MERONEM MEROPEN MEROPENEM MERREM;Meronem
Product Categories:Active Pharmaceutical Ingredients;Antibacterial;Cnbio;pharmaceutical intermediates;ARAVA
Mol File:96036-03-2.mol
Meropenem Structure
Meropenem Chemical Properties
Boiling point 627.4±55.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
CAS DataBase Reference96036-03-2(CAS DataBase Reference)
EPA Substance Registry SystemMeropenem (96036-03-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
HS Code 29419000
MSDS Information
Meropenem Usage And Synthesis
Brand Name(s) in USMerrem
Semi-synthetic carbapenem antibioticsMeropenem is another kind of parenteral administrated semi-synthetic carbapenem antibiotics after imipenem-cilastatin has entered into market in the United State. It can inhibit the bacterial cell wall synthesis through binding with the penicillin-binding proteins involved in cell wall synthesis (PBPs) through its covalent bond, thus playing its antibacterial effect. Both Gram-positive bacteria and Gram-negative bacteria are sensitive to it. It has a particular strong antibacterial activity against gram negative bacteria. For example, the minimum inhibitory concentration (MIC) of it on about 90% of Enterobacter was about 0.08-0.15mg/L with more than 90% of the Pseudomonas aeruginosa strains (MIC <4mg/L) being highly sensitive to it as well as all Haemophilus including their ampicillin-resistant strains being highly sensitive to it (MIC of 0.06-1mg/L). Neisseria gonorrhoeae is also highly sensitive to meropenem whose activity is 15 fold as high as imipenem. Staphylococcus epidermidis, Staphylococcus saprophyticus and other coagulase-negative staphylococci is also sensitive to meropenem. The majority strains of Enterococcus faecalis are highly or moderately sensitive to meropenem. A concentration of MIC (0.06-4mg/L) of meropenem can almost suppress all of Bacteroides fragilis. Anaerobe such as Peptostreptococcus, Propionibacterium, and Actinomyces are also sensitive to meropenem.
IndicationsClinically, meropenem is suitable for treating the following infections caused by susceptible strains:
1. Respiratory infections such as chronic bronchitis, nosocomial pneumonia, lung abscess and empyema.
2. Intra-abdominal infections such as cholecystitis, cholangitis, liver abscess and peritonitis.
3. Urinary and reproductive system infections, such as pyelonephritis and complicated cystitis, endometritis, adnexitis, intrauterine infections, pelvic inflammatory disease and uterine connective tissue.
4. Bones, joints and skin and soft tissue infections such as cellulitis, anal abscess, osteomyelitis, arthritis, trauma, wound infection, burn wound infections, surgical wound infections, maxilla and mandible surrounding cellulitis.
5. Eye and ENT infections.
6. Empirical treatment; for patients of adult neutropenia with fever, the drug can be used alone or be used in combination with antiviral or antifungal drugs.
7. It can be used either alone or in combination with other anti-microbial agents for the treatment of complex infections.
8. Other serious infections, such as meningitis, septicemia.
Antibacterial scopeGram-positive aerobes: Staphylococcus aureus (including β-lactamase producing strains), Staphylococcus epidermidis (including β-lactamase producing strains), Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Enterococcus faecalis, Enterococcus feces, Nocardia, and Listeria monocyogenes.
Gram-negative aerobic bacteria: Klebsiella, Klebsiella ozaenae, Klebsiella pneumoniae, Legionella spp., Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Pseudomonas, Pseudomonas aeruginosa, Morganella morganii, Salmonella, Salmonella typhi (including β-lactamase producing strains), Serratia, Shigella, Yersinia, deformation spp, Pasteurella spp., Neisseria gonorrhoeae, Citrobacter spp., Haemophilus, Haemophilus influenzae, Alcaligenes, Acinetobacter spp., and Campylobacter spp.
Gram-positive anaerobic bacteria: Actinomyces, Clostridium, Peptococcus, Peptostreptococcus and Propionibacterium.
Gram-negative anaerobic bacteria: Bacteroides, Bacteroides fragilis, Fusobacterium gangrene and veillonella.
Comparison among three kinds of carbapenems antibioticsMeropenem, imipenem and panipenem, all these three kinds of carbapenems class antibiotics have good antibacterial activity against all kinds of G + and G-bacteria, aerobe and anaerobe. Clinically it is mostly used for treating the severe infection, mixed infection, nosocomial infection and immuno-deficient infection caused by enzyme-producing strain, and multi-drug resistant strains as well as G-strain.
The differences between the three antibiotics are as follows:
1, each of them has their own focus regarding its antibacterial effect. They have a similar antibacterial spectrum against the anaerobes. For aerobic non-fermentation gram negative bacteria, meropenem has the strongest antibacterial activity, followed by imipenem, panipenem. For G+ bacteria, panipenem has the strongest antibacterial activity.
2, for the adverse reactions of the central nervous system, the imipenem can cause the highest incidence with the incidence of the meropenem and panipenem being low.
3, Imipenem is unstable under the reaction of human renal dehydropeptidase, thus should be used in combination with the enzyme inhibitor cilastatin. Meropenem and panipenem is stable to the human renal dehydropeptidase. Panipenem have some extent of kidney toxicity with often being used together with betamethasone in order to reduce the nephrotoxicity.
4, imipenem and panipenem is only be available for intravenous injection. Intramuscular injection can also be applied for administration of meropenem.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
DosageMeropenem injection Specification: 0.5g; 0.25g.
Solution preparation:
After dilution with a suitable solution, within 15 to 30 min, apply intravenous infusion or intravenous injection via dilution with sterile water in 3-5 minutes.
Intravenous administration: General dose: administer of 500 mg-1000 mg every eight hours. Dose upon severe infection: administer 500-2000 mg of drug every 8 hour.
Medication for special Populations:
1. Dose of renal insufficiency: for patients of creatinine clearance rate being 26mL/min-50mL/min, administer 1000 mg of drug at every 12 hours; for patients of creatinine clearance rate being 10mL/min-25mL/min, administer 500 mg of drug at every 12 hour; for patients with creatinine clearance being less than 10 mL/min, administer 500 mg of drug at every 24 hour.
2. Dose of patients of liver dysfunction: patients of mild liver dysfunction don’t need dose adjustment.
3. Dose of elderly patients: the elderly should reduce the dose due to prolonged half-life.
4. The dose upon dialysis: dialysis patients are recommended to increase the dose during hemodialysis.
Pediatric dose should be 10-20mg/kg with 3 times a day.
Side effectsSerious adverse reactions are rare. Adverse reactions observed in clinical trials include the following:
1, inflammation in the injection site inflammation, thrombophlebitis and pain in injection site.
2, Rash, itching, and hives.
3, abdominal pain, nausea, vomiting, diarrhea.
4, reversible eosinophilia, thrombocytopenia, and neutropenia. Positive results in direct or indirect Coombs test occurred in some patients.
5, the concentration of serum bilirubin, transaminases, alkaline phosphatase and lactate dehydrogenase can reversibly increases.
6, headache and paresthesia.
7, oral and vaginal candidiasis.
Drug Interactions1. Combined therapy with probenecid can reduce the plasma clearance of meropenem while extending the half-life of meropenem.
2. Simultaneous application of typhoid vaccine may interfere with the immune response of live typhoid vaccine.
3. It has been reported that combination with antiepileptic drugs can reduce the plasma concentrations of anti-epileptic drugs.
4. Combination with zidovudine, ondansetron, vitamins, doxycycline, diazepam, calcium gluconate and acyclovir belong to combination compatibility.
UsesIt is a kind of anti-infection drugs and a kind of antibiotics.
DescriptionMeropenem is a new carbapenem antibiotic introduced to market for the i.v. treatment of a wide variety of hospital infections such as lower respiratory tract, urinary tract, intraabdominal, gynecological and polymicrobial infections. Meropenem has a broad spectrum of antibacterial activity against most clinically important Gram-positive and Gramnegative aerobic and anaerobic bacteria with especially high potency against multiresistant Enterobacteriaceae and Pseudornonas aeruginosa. Compared with imipenem, the only other available carbapenem antibiotic, meropenem has the advantage of being dehydropeptidase 1 (DHP-1) stable and therefore does not need to be administered in conjunction with the DHP-1 inhibitor cilastatin. Meropenem is also being evaluated for treatment of resistant pseudomonal infections in cystic fibrosis patients.
Chemical Properties1KG;
OriginatorSumitomo (Japan)
Usesantineoplastic, PDGF receptor blocker, immunomodulator
Brand nameMerrem I.V. (AstraZeneca).
Meropenem Preparation Products And Raw materials
Tag:Meropenem(96036-03-2) Related Product Information
BenzylFormimidate-Hydrochloride,IntermediateOfImipenem,Meropenem,(CarbopenemDrug) desmethyl meropenem Meropenem Sodium MEROPENEM Meropenem,Imipenem,Cinnarizine Intermediates Of Imipenem & Meropenem (Carbopenem Drug) MAP/MVP-INTERMEDIATE OF MEROPENEM Meropenem and lmipenem intermediates series 1-Methyl-2-pyrrolidinone Meropenem Sodium Salt,MEROPENEM SIDE CHAIN,DMP-INTERMEDIATE OF MEROPENEM,SIDE CHAIN FOR MEROPENEM,Side chain for Meropenem(2S-CIS),SIDE CHAIN FOR MEROPENEM 97+%(HPLC) 3-(2-Bromo-1-oxopropyl)-spiro[2H-1,3-benzoxazine-2,1'-cyclohexan]-4(3H)-one N-Vinyl-2-pyrrolidone Meropenem Pyrrolidine Thioacetic acid Polyvinylpyrrolidone Thioacetamide Sodium thiosulfate pentahydrate