|
|
| | (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Basic information |
| | (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Chemical Properties |
| Melting point | 46-49 °C(lit.) | | Boiling point | 105-107 °C1 mm Hg(lit.) | | alpha | D25 +68.5 ± 1.3° (c = 1.49 in CH3OH) | | density | 1.344 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.473(lit.) | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | Soluble in methanol (50 mg/ 1 ml). | | pka | 1.47±0.10(Predicted) | | form | Crystalline Low Melting Solid | | Specific Gravity | 1.344 | | color | White | | optical activity | [α]20/D +73±1°, c = 2% in methanol | | Sensitive | Hygroscopic | | Merck | 14,6280 | | BRN | 2215440 | | CAS DataBase Reference | 20445-31-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 3-10 | | Hazard Note | Irritant/Keep Cold | | HazardClass | IRRITANT, HYGROSCOPIC, KEEP COLD | | HS Code | 29189900 |
| | (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Usage And Synthesis |
| Chemical Properties | white crystalline low melting solid | | Uses | (R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR. | | Uses | Mosher′s acid chloride is used as a dervatization agent for β-arylethylamines, enantiomeric alcohols, and enantiomeric amines. It is also a reagent used for the determination of enantiomeric purity and absolute configuration of alcohols and amines by NMR. | | General Description | Mosher′s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines. | | Purification Methods | A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.] |
| | (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Preparation Products And Raw materials |
|