Zoxazolamine Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Email: sales@capotchem.com
Products Intro: Product Name:2-Amino-5-chlorobenzoxazole
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Zoxazolamine
Purity:99% Package:1kg;8USD
Company Name: Nanjing Dolon Biotechnology Co.,Ltd.
Tel: 18905173768
Email: sales@dolonchem.com
Products Intro: CAS:61-80-3
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:Zoxazolamine
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:5-Chlorobenzo[d]oxazol-2-amine
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-61945

Lastest Price from Zoxazolamine manufacturers

  • Zoxazolamine
  • US $8.00 / kg
  • 2019-07-06
  • CAS:61-80-3
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 10TON
Zoxazolamine Basic information
Product Name:Zoxazolamine
Synonyms:2-AMINO-5-CHLOROBENZOXAZOLE;usafma-12;Zoxamin;Zoxine;TIMTEC-BB SBB003874;ZOXAZOLAMINE;2-Amino-5-chlorobenzoxazole,97%;2-Amino-5-chlorobenzoxazoleZoxazolamine
Product Categories:Miscellaneous;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;SPLENDA
Mol File:61-80-3.mol
Zoxazolamine Structure
Zoxazolamine Chemical Properties
Melting point 181-184 °C(lit.)
Boiling point 316.8±34.0 °C(Predicted)
density 1.4369 (rough estimate)
refractive index 1.5618 (estimate)
storage temp. Keep in dark place,Sealed in dry,2-8°C
form Powder
color Light brown to yellow-brown
Merck 13,10249
CAS DataBase Reference61-80-3(CAS DataBase Reference)
NIST Chemistry ReferenceZoxazolamine(61-80-3)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS DM4550000
HS Code 29349990
ToxicityLD50 in mice, rats (mg/kg): 376, 102 i.p.; 678, 730 orally (Cain, Roszkowski)
MSDS Information
ACROS English
SigmaAldrich English
Zoxazolamine Usage And Synthesis
OriginatorFlexin ,McNeil,US,1956
UsesZoxazolamine is a centrally acting myorelaxant; formerly used as an antispasmodic and uricosuric. Used as a tool for assessing hepatic cytochrome P-450 activity in rodents.
Manufacturing ProcessTo a solution of 106 g (0.74 mol) of 2-amino-4-chlorophenol in 500 ml of water containing 69 ml of concentrated hydrochloric acid (29.2 g, 0.8 mol) are added 60.8 g (0.8 mol) of ammonium thiocyanate. The solution is placed in an evaporating dish and heated on a steam bath for 5 hours. The solid which results is then removed from the concentrated solution by filtration, washed with a small amount of water and dried. The filtrate is placed in an evaporating dish and heated on a water bath for 2 hours. At the end of this time, the mixture is cooled, and the solid which precipitates out is removed by filtration. Both solid products are 5-chloro-2-hydroxyphenylthiourea melting at 157°C, and may be combined. The calculated N content for C 7 H 7 ClN 2 OS is 13.8; that found is 13.6.
To a solution of 10 g (0.05 mol) of 2-hydroxy-5-chlorophenylthiourea in 50 ml of methanol is added a solution of 11 g (0.04 mol) of ferric chloride hexahydrate in 50 ml of methanol. The initial purple-red color changes in a few minutes to amber. After stirring for one half hour, the solution is treated with 16.5 ml of 57% ammonium hydroxide solution (0.24 mol). A brown, flocculent precipitate of ferric sulfide appears. The mixture is then refluxed with stirring for one hour, cooled and centrifuged. The centrifugate is evaporated to dryness, and the residue is shaken with ether and water to separate the organic material from the ammonium chloride. The ether layer is extracted three times with 25 ml portions of 1 N hydrochloric acid. The acid solution is then poured into excess ammonium hydroxide, and the resulting solid collected, washed with water and dried. This gives a light tan solid melting at 183°C to 185°. The material is then dissolved in 25 ml of acetone and 50 ml of benzene are added. After treatment of the solution with activated charcoal, the light yellow solution is evaporated to 25 ml and cooled. The white crystals of 2-amino-5-chlorobenzoxazole which separate melt at 185°C to 186°C.
Therapeutic FunctionMuscle relaxant, Uricosuric
Zoxazolamine Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Ammonium thiocyanate-->2-Amino-4-chlorophenol-->Ferric chloride-->Ammonium hydroxide
Preparation Products2,5-Dichlorobenzooxazole
Tag:Zoxazolamine(61-80-3) Related Product Information
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