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| | 4'-Hydroxy-3'-methylacetophenone Basic information |
| | 4'-Hydroxy-3'-methylacetophenone Chemical Properties |
| Melting point | 107-109 °C(lit.) | | Boiling point | 175°C 1mm | | density | 1.0858 (rough estimate) | | refractive index | 1.5180 (estimate) | | Fp | 175°C/1mm | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 8.52±0.18(Predicted) | | form | Solid | | color | Off-White to Pale Beige | | BRN | 2041839 | | Stability: | Hygroscopic | | LogP | 1.395 (est) | | CAS DataBase Reference | 876-02-8(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Hydroxy-3-methylacetophenone(876-02-8) |
| | 4'-Hydroxy-3'-methylacetophenone Usage And Synthesis |
| Chemical Properties | white to light beige crystalline powder or | | Uses | 4''-Hydroxy-3''-methylacetophenone is used in the synthesis of 3-De(hydroxymethyl)-3-methyl Salmeterol (D230650), which is an impurity of β2-Adrenergic agonist Salmeterol (S090100). | | Preparation | Preparation by dealkylation of 4-hydroxy-5-methyl-2-iso-propylacetophenone with aluminium chloride in chloro-benzene at 50° (53%). | | Definition | ChEBI: 4-hydroxy-3-methylacetophenone is a monohydroxyacetophenone that is acetophenone carrying methyl and hydroxy groups at positions 3 and 4, respectively. It has a role as a volatile oil component and an insect attractant. It is a monohydroxyacetophenone, a member of phenols and a hydroxytoluene. It is functionally related to an acetophenone. | | Synthesis Reference(s) | Journal of Medicinal Chemistry, 23, p. 738, 1980 DOI: 10.1021/jm00181a008 |
| | 4'-Hydroxy-3'-methylacetophenone Preparation Products And Raw materials |
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