|
|
| | 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE Basic information |
| Product Name: | 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE | | Synonyms: | DPCPX, PD 116,948;8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE(DPCPX,1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE);cyclopentyl-1,3-dipropylxanthine;1,3-Dipropyl-8-cyclopentylxanthine, DPCPX, PD 116,948;1,3-Dipropyl-8-cyclopentyl-7H-purine-2,6(1H,3H)-dione;8-Cyclopentyl-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione;1,3-Dpcpx;1H-Purine-2,6-dione, 8-cyclopentyl-3,7-dihydro-1,3-dipropyl- | | CAS: | 102146-07-6 | | MF: | C16H24N4O2 | | MW: | 304.39 | | EINECS: | | | Product Categories: | Adenosine receptor;All Inhibitors;Inhibitors;Heterocycles;Neurochemicals | | Mol File: | 102146-07-6.mol |  |
| | 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE Chemical Properties |
| Melting point | 178°C | | Boiling point | 535.1±42.0 °C(Predicted) | | density | 1.195±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMSO: >10 mg/mL | | pka | 9.01±0.70(Predicted) | | form | solid | | color | white | | Stability: | Store tightly sealed at RT; Solutions at 4 deg C for several days | | CAS DataBase Reference | 102146-07-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | 8-Cyclopentyl-1,3-dipropylxanthine has been used as an adenosine receptor (A1AR) antagonist in macrophages and human umbilical vein endothelial cells (HUVECs). It has also been used as A1AR antagonist in MCF-7 breast cancer cell line to test its anti-cancer effect. | | Uses | DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes. Its 740-fold A1-selectivity is the highest reported for an adenosine antagonist | | Definition | ChEBI: An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group. | | Biological Activity | Potent and selective A 1 adenosine receptor antagonist, both in vitro and in vivo . K i values are 3.9, 130, 50 and 4000 nM for human A 1 , A 2A , A 2B and A 3 receptors respectively. | | Biochem/physiol Actions | 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) is a selective A1?adenosine receptor antagonist. DPCPX possesses anti-cancer functionality. It induces apoptosis in breast cancer cells and favors mRNA expression of caspases. | | storage | Room temperature |
| | 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE Preparation Products And Raw materials |
|